Recombinant monoclonal antibody specially binds to E2 derived from HCV of both genotype 1b. This human anti-E2 antibody (L1) can be potencially used in the neutralization of HCV in patients with HCV infection.
Figure 1 Indirect immunofluorescence analysis.
Staining was performed using goat-anti human IgG immune serum coupled with fluoresceine.
Habersetzer, F., Fournillier, A., Dubuisson, J., Rosa, D., Abrignani, S., Wychowski, C., ... & Inchauspé, G. (1998). Characterization of Human Monoclonal Antibodies Specific to the Hepatitis C Virus Glycoprotein E2 within VitroBinding Neutralization Properties. Virology, 249(1), 32-41.
Figure 2 Immunoprecipitation of E2 and coprecipitation of E1 and analysis of epitope formation under under reducing and nonreducing conditions.
Expected position of HCV-specific proteins are indicated at the left of the figures.
Habersetzer, F., Fournillier, A., Dubuisson, J., Rosa, D., Abrignani, S., Wychowski, C., ... & Inchauspé, G. (1998). Characterization of Human Monoclonal Antibodies Specific to the Hepatitis C Virus Glycoprotein E2 within VitroBinding Neutralization Properties. Virology, 249(1), 32-41.
Figure 3 Percent neutralization of E2 binding by HCV-E2 HMAbs.
Various concentrations of anti-E2 HMAbs were tested for their ability to neutralize binding of purified CHO-expressed E2 protein onto MOLT-4 cells.
Habersetzer, F., Fournillier, A., Dubuisson, J., Rosa, D., Abrignani, S., Wychowski, C., ... & Inchauspé, G. (1998). Characterization of Human Monoclonal Antibodies Specific to the Hepatitis C Virus Glycoprotein E2 within VitroBinding Neutralization Properties. Virology, 249(1), 32-41.
Figure 4 Antibody response to E1, E2, and the E2 HVR-1.
Serial bleeds obtained up to 9 years postinoculation with HCV from chimpanzee x174 were examined by ELISA for reactivity to native, purified E1 and E2, and a synthetic peptide to the HVR-1.
Aytug, S., Reich, D., Sapiro, L. E., Bernstein, D., & Begum, N. (2003). Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology, 38(6), 1384-1392.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-938 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment | ELISA, IHC | scFv |
PSBC-282 | Recombinant Human Anti-HCV E2 Antibody scFv Fragment (HC26AM) | ELISA, Neut | Human scFv |
PSBC-319 | Recombinant Mouse Anti-HCV E2 Antibody scFv Fragment (DAO5) | ELISA, FC | Mouse scFv |
HPAB-0156-YJ-S(P) | Recombinant Human Anti-HCV E2 Protein Antibody scFv Fragment (e2d066) | ELISA, Inhib | Human scFv |
FAMAB-0174WJ-S(P) | Human Anti-HCV E2 Recombinant Antibody (clone 212.1.1); scFv Fragment | ELISA, WB, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-446 | Recombinant Anti-HCV E2 Antibody | ELISA, WB, Dot, FuncS | IgG |
HPAB-0005-WJ | Recombinant Human Anti-HCV E2 Antibody (HC-84.1) | Neut, ELISA, IP, IF | Human IgG1 |
PABC-415 | Human Anti-HCV E2 Protein Recombinant Antibody (PABC-415) | ELISA, IP, Neut, Inhib, FC | Human IgG1 |
HPAB-0234-FY | Recombinant Human Anti-HCV E2 Antibody (TRN1008) | E, N | Human IgG |
HPAB-0156-YJ | Recombinant Human Anti-HCV E2 Protein Antibody (e2d066) | ELISA, Inhib | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-492 | Mouse Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (PFBL-492) | ELISA, Neut | Mouse Fab |
PFBL-493 | Recombinant Mouse Anti-HCV E2 Antibody Fab Fragment (AP33) | ELISA | Fab |
PFBL-494 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (AR3C) | Neut | Fab |
PFBL-495 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (C2) | Neut | Fab |
PFBL-496 | Recombinant Human Anti-HCV E2 Antibody Fab Fragment (HC33.8) | Neut | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-437LC | Anti-HCV E2 Recombinant Antibody (503) | ELISA | Human antibody |
MRO-438LC | Anti-HCV E2 Recombinant Antibody (108) | ELISA | Human antibody |
MRO-437LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (503) | ELISA | Human antibody |
MRO-438LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (108) | ELISA | Human antibody |
MRO-467LC-F(E) | Anti-HCV E2 Recombinant Antibody Fab Fragment (7F2) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-476LC | Human Anti-HCV E2 Protein Recombinant Antibody (MRO-476LC) | ELISA, Inhib | Chimeric (mouse/human) IgG |
MRO-476LC-S(P) | Mouse Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-476LC-S(P)) | ELISA | Mouse scFv |
MRO-476LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-476LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-478LC-S(P) | Human Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-478LC-S(P)) | ELISA | Humanized scFv |
MRO-479LC-S(P) | Human Anti-HCV E2 Protein Recombinant Antibody; scFv Fragment (MRO-479LC-S(P)) | ELISA | Humanized scFv |
MRO-477LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-477LC-F(E)) | ELISA | Humanized Fab |
MRO-478LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-478LC-F(E)) | ELISA | Humanized Fab |
MRO-479LC-F(E) | Human Anti-HCV E2 Protein Recombinant Antibody; Fab Fragment (MRO-479LC-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1191LC | Anti-HCV E2 Recombinant Antibody (A10F2) | ELISA, Inhib | Mouse Antibody |
MRO-1192LC | Anti-HCV E2 Recombinant Antibody (H6D3) | ELISA, Inhib, WB | Mouse Antibody |
MRO-1193LC | Anti-HCV E2 Recombinant Antibody (E3D8) | ELISA, Inhib, WB | Mouse Antibody |
MRO-1194LC | Anti-HCV E2 Recombinant Antibody (A7A6H9) | ELISA, Inhib | Mouse Antibody |
MRO-1195LC | Anti-HCV E2 Recombinant Antibody (G9E1) | ELISA, Inhib | Mouse Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC428 | PE-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM | |
MHC-LC429 | APC-A*24:02/HCV E2 (EYVLLLFLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0065LC | Recombinant Mouse Anti-HCV E2 protein Antibody (JS-81) | ELISA | IgG1 |
EPAF-1294LC | Recombinant Human Anti-HCV E2 protein Antibody (4c2) | ELISA |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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