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  • Rabbit Anti-HIP1 Recombinant Antibody (clone R09-7O3)

Rabbit Anti-HIP1 Recombinant Antibody (clone R09-7O3) (CAT#: VS3-XY3380)

The product is a recombinant rabbit antibody specific for HIP1 (Huntingtin interacting protein 1), which involves in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. It recognizes human HIP1 and it also has cross reactivity against mouse or rat HIP1. This product has been reported for use in Western blot, Immunoprecipitation, Immunocytochemistry or Immunofluorescence.


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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/38191_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/38191_A_8_3.jpg
Figure 4 Liver
Figure 4 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/38191_A_7_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/38191_A_8_5.jpg
Figure 6 Testis
Figure 6 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Low Intensity: Weak Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/38191_A_6_6.jpg
Figure 7 Lymph node
Figure 7 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13606/38191_A_7_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A549)
Figure 8 RNA cell line category: Cell line enhanced (A549)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000127946-HIP1

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat HIP1
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R09-7O3
  • Applications
  • WB, ICC, IF, IP
  • Related Disease
  • Chronic Myelomonocytic Leukemia; Huntington Disease

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000
    IF: 1/50-1/200
    IP: 1/20

Target

  • Alternative Names
  • SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma
  • Long Name
  • Huntingtin interacting protein 1
  • Cellular Localization
  • Cytoplasm, Nucleus, Endomembrane system, Cytoplasmic vesicle
  • Post Translation Modifications
  • Ubiquitination at Lys9 and Lys17 (NX_O00291 [NX_O00291-1])
    Modification sites at PhosphoSitePlus (O00291)
    Glycosylation from GlyGen (O00291) 1 site, 1 O-linked glycan (1 site)
  • Function
  • Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, 11577110, 11889126).
    Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity).
    Regulates presynaptic nerve terminal activity (By similarity).
    Enhances androgen receptor (AR)-mediated transcription.

Recommended Products

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "HIP1"

Recombinant Antibody

CAT Product Name Application Type
MOB-3528z Mouse Anti-HIP1 Recombinant Antibody (clone 15C10) WB, IP, IF Mouse IgG1, κ
MOB-1824MZ Recombinant Mouse Anti-Human HIP1 Antibody (clone 2C22) ELISA, IHC-Fr, IHC-P, WB Mouse antibody
MRO-1930-CN Rabbit Anti-HIP1 Polyclonal Antibody (MRO-1930-CN) WB, IF, IHC, FC Rabbit IgG
VS3-QX511 Mouse Anti-HIP1 Recombinant Antibody (clone 13E1) WB, ICC, IHC Mouse IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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