Recombinant mouse antibody to gp160(727-732). C8 recognizes PDRPEG on the surface of HIV-1 infected cells, but not on virions and is non-neutralizing.
Figure 1 Western blot of thermolysin-treated virus (T), mock-treated virus (M) and untreated virus (V). Purified virus was digested with thermolysin (10 mg ml21 ) for 1 h on ice.
Virus preparations (T, M) were centrifuged free of soluble protein.
Cleveland, S. M., McLain, L., Cheung, L., Jones, T. D., Hollier, M., & Dimmock, N. J. (2003). A region of the C-terminal tail of the gp41 envelope glycoprotein of human immunodeficiency virus type 1 contains a neutralizing epitope: evidence for its exposure on the surface of the virion. Journal of General Virology, 84(3), 591-602.
Figure 2 Neutralization of HIV-1 IIIB by antibodies specific for the gp41 epitope.
Neutralization was determined by inhibition of syncytium production.
Cleveland, S. M., McLain, L., Cheung, L., Jones, T. D., Hollier, M., & Dimmock, N. J. (2003). A region of the C-terminal tail of the gp41 envelope glycoprotein of human immunodeficiency virus type 1 contains a neutralizing epitope: evidence for its exposure on the surface of the virion. Journal of General Virology, 84(3), 591-602.
Figure 3 Hetero-oligomerization is inhibited by multiple alanine substitutions in the gp41 amphipathic a-helical sequence.
RODtag or HIV-1 gp160 were coexpressed with the HIV-2 1-589 mutant containing an unmodified a-helix
(pR589 and pB589) or a multiply Ala-substituted a-helix (pR589A9 and
pB589A9) in HeLa cells.
Center, R. J., Kemp, B. E., & Poumbourios, P. A. N. T. E. L. I. S. (1997). Human immunodeficiency virus type 1 and 2 envelope glycoproteins oligomerize through conserved sequences. Journal of virology, 71(7), 5706-5711.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-382 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08) | Neut, FuncS | Human IgG, κ |
PABL-554 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC16.01) | FC, Neut | Human IgG |
PABL-555 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone C38-VRC18.02) | FC, Neut | Human IgG |
PABL-556 | Human Anti-HIV-1 gp160 Recombinant Antibody (PABL-556) | Neut | Human IgG |
PABL-557 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone Z258-VRC27.01) | FC, Neut | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-382 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone VRC08); Fab Fragment | Neut, FuncS | Human Fab |
PSBW-163 | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 268-D); scFv Fragment | ELISA, Neut | Human scFv |
MRO-3673CQ-F(E) | Chimpanzee Anti-HIV-1 gp160 Recombinant Antibody (clone C311E); Fab Fragment | Neut | Chimpanzee Fab |
MRO-3674CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone HGN35); Fab Fragment | ELISA | Human Fab |
MRO-3675CQ-F(E) | Human Anti-HIV-1 gp160 Recombinant Antibody (clone 10-188); Fab Fragment | ELISA, Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-086LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1C1) | ELISA | Mouse antibody |
MRO-087LC-S(P) | Anti-HIV-1 gp160 Recombinant Antibody scFv Fragment (1H9) | ELISA | Mouse antibody |
MRO-086LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1C1) | ELISA | Mouse antibody |
MRO-087LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (1H9) | ELISA | Mouse antibody |
MRO-088LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (2D7) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-075LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (24G3) | ELISA | Human antibody |
MRO-080LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (81C7) | ELISA | Human antibody |
MRO-091LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (MAb CL1) | ELISA | Human antibody |
MRO-100LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (N7019b) | ELISA | Human antibody |
MRO-101LC-F(E) | Anti-HIV-1 gp160 Recombinant Antibody Fab Fragment (K24-3b) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-4023CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone 11/4b); scFv Fragment | Neut | Rat scFv |
MRO-4024CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone ICR38.1a (38.1a, 388/389, ARP388/389)); scFv Fragment | Neut | Rat scFv |
MRO-4025CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone ICR38.8f); scFv Fragment | Neut | Rat scFv |
MRO-4026CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone M91); scFv Fragment | ELISA, WB | Rat scFv |
MRO-4044CQ-S(P) | Rat Anti-HIV-1 gp160 Recombinant Antibody (clone 75); scFv Fragment | ELISA, IHC | Rat scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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