Provided is a monoclonal antibody (clone B402) specially binds to SIV gp41. This Rhesus macaque anti-gp41 antibody (B402) will be useful to analyze the mechanism of broad neutralization using the SIV macaque model.
Figure 1 ELISA binding of mAb to gp140, gp120, gp41.
Error bars denote one standard error of the mean (SEM).
Huang, J., Ofek, G., Laub, L., Louder, M. K., Doria-Rose, N. A., Longo, N. S., ... & Alam, S. M. (2012). Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature, 491(7424), 406-412.
Figure 2 The mechanism of complement‐mediated inhibition of antibody binding to HIV gp41.
Original magnification ×200.
Hidvegi, T., Prohászka, Z., Ujhelyi, E., Thielens, N. M., Dierich, M. P., Hampl, H., ... & Füst, G. (1993). Studies on the mechanism of complement‐mediated inhibition of antibody binding to HIV gp41. Clinical & Experimental Immunology, 94(3), 490-493.
Figure 3 Staining of HIV-infected and uninfected cells by mAbs to gp41 cytoplasmic domain.
The gp41 mAbs were incubated at the concentrations shown with HIV-l-infected H9 cells which had been pretreated or not with sCD4.
Sattentau, Q. J., Zolla-Pazner, S., & Poignard, P. (1995). Epitope exposure on functional, oligomeric HIV-1 gp41 molecules. Virology, 206(1), 713-717.
Figure 4 Immunoreactivity of a HIV antibody-positive serum with different ENV(80) subfragments.
M15 cells harbouring pDMI,1 and in addition the plasmid constructs encoding the hybrid proteins.
Sattentau, Q. J., Zolla-Pazner, S., & Poignard, P. (1995). Epitope exposure on functional, oligomeric HIV-1 gp41 molecules. Virology, 206(1), 713-717.
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• Increased sensitivity
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-471 | Recombinant Anti-HIV gp41 Antibody | ELISA, IP, FuncS | IgG |
MHH-471 | Recombinant Human Anti-HIV gp41 Antibody | RIA, WB, FuncS | IgG |
PABL-139 | Human Anti-HIV gp41 (596-606) Recombinant Antibody (clone 7B2) | Neut, FC, FuncS | Human IgG1, κ |
HPAB-1987-FY | Human Anti-HIV gp41 Recombinant Antibody (clone Z13) | ELISA, FC | Human IgG, κ |
FAMAB-0099WJ | Human Anti-HIV gp41 Recombinant Antibody (clone 120-16) | ELISA | Human IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-471-F(E) | Recombinant Anti-HIV gp41 Antibody Fab Fragment | RIA, WB, FuncS | Fab |
MHH-471-F(E) | Recombinant Human Anti-HIV gp41 Antibody Fab Fragment | IP, IF, Biosensors, FuncS | Fab |
PFBL-139 | Human Anti-HIV gp41 (596-606) Recombinant Antibody (clone 7B2); Fab Fragment | Neut, FC, FuncS | Human Fab |
HPAB-1987-FY-F(E) | Human Anti-HIV gp41 Recombinant Antibody (clone Z13); Fab Fragment | FC, Neut | Human Fab, κ |
FAMAB-0099WJ-F(E) | Human Anti-HIV gp41 Recombinant Antibody (clone 120-16); Fab Fragment | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-139 | Human Anti-HIV gp41 (596-606) Recombinant Antibody (clone 7B2); scFv Fragment | Neut, FC, FuncS | Human scFv |
HPAB-1987-FY-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone Z13); scFv Fragment | FC, Neut | Human scFv |
FAMAB-0082WJ-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone NO.86); scFv Fragment | ELISA, WB | Human scFv |
FAMAB-0099WJ-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone 120-16); scFv Fragment | ELISA | Human scFv |
FAMAB-0262JF-S(P) | Monkey Anti-HIV gp41 Recombinant Antibody (clone B402); scFv Fragment | FC, ELISA, FuncS | Monkey scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-092CT-S(P) | Human Anti-HIV gp41 Recombinant Antibody; scFv Fragment (TAB-092CT-S(P)) | ELISA, Neut | Human scFv |
TAB-092CT-F(E) | Human Anti-HIV gp41 Recombinant Antibody; Fab Fragment (TAB-092CT-F(E)) | ELISA, Neut | Human Fab |
PABX-064 | Human Anti-HIV gp41 Recombinant Antibody (clone Z13e1) | WB, Neut, FuncS, ELISA | Human IgG1, λ |
PABX-064-F(E) | Human Anti-HIV gp41 Recombinant Antibody (clone Z13e1); Fab Fragment | WB, Neut, FuncS, ELISA | Human Fab |
PABX-064-S(P) | Human Anti-HIV gp41 Recombinant Antibody (clone Z13e1); scFv Fragment | WB, Neut, FuncS, ELISA | Human scFv |
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