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  • Rabbit Anti-HSP90B1 Recombinant Antibody (clone R02-9F8)

Rabbit Anti-HSP90B1 Recombinant Antibody (clone R02-9F8) (CAT#: VS3-XY3388)

The product is a recombinant rabbit antibody that recognizes HSP90B1 (Heat shock protein 90 beta family member 1), which participates in the unfolding of cytosolic leaderless cargos. It is capable of binding to human and mouse HSP90B1. It has been used in a variety of applications, such as Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.


See more Engineered Antibody products for HSP90B1
Specific Inquiry
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  • Gene Expression
  • Datasheet
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3901/if_selected.jpg
Figure 2 IF staining of human cell line A431
Figure 2 IF staining of human cell line A431
(Immunofluorescent staining of human cell line A431 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3901/14_F12_1_blue_red_green.jpg
Figure 3 IF staining of human cell line U-251 MG
Figure 3 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3901/16_F12_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Figure 4 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23098_B_7_5.jpg
Figure 5 Thyroid gland
Figure 5 Thyroid gland
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23098_B_3_5.jpg
Figure 6 Colon
Figure 6 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23452_A_9_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23452_A_9_4.jpg
Figure 8 Kidney
Figure 8 Kidney
(Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%
Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23452_A_7_5.jpg
Figure 9 Testis
Figure 9 Testis
(Pachytene spermatocytes
Staining:Medium
Intensity: Strong
Quantity: <25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23452_A_6_6.jpg
Figure 10 Lymph node
Figure 10 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8424/23452_A_9_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Figure 11 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000166598-HSP90B1

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human and Mouse HSP90B1
  • Species Reactivity
  • Human, Mouse
  • Clone
  • R02-9F8
  • Applications
  • WB, IHC-P, ICC, IF
  • Related Disease
  • Pelizaeus-Merzbacher-Like Disease; Pseudoachondroplasia

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000
    IHC: 1/50-1/100
    IF: 1/50-1/200

Target

  • Alternative Names
  • ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m
  • Long Name
  • Heat shock protein 90 beta family member 1
  • Cellular Localization
  • Endoplasmic reticulum lumen, Sarcoplasmic reticulum lumen, Melanosome
  • Post Translation Modifications
  • Glycosylation at Asn62, Asn107, Asn217, Asn445, Asn481, and Asn502 (NX_P14625 [NX_P14625-1])
    Ubiquitination at Lys75, Lys142, Lys161, Lys168, Lys270, Lys434, and Lys671 (NX_P14625 [NX_P14625-1])
    Modification sites at PhosphoSitePlus (P14625)
    Glycosylation from GlyConnect ENPL_HUMAN (1206)
    Glycosylation from GlyGen (P14625) 14 sites, 19 N-linked glycans (5 sites), 2 O-linked glycans (6 sites)
  • Function
  • Molecular chaperone that functions in the processing and transport of secreted proteins (By similarity).
    When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity).
    Functions in endoplasmic reticulum associated degradation (ERAD) (PubMed:18264092).
    Has ATPase activity.

Recommended Products

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "HSP90B1"

Single-domain Antibody

CAT Product Name Application Type
NAB-1330-VHH Recombinant Anti-Human HSP90B1 VHH Single Domain Antibody FUNC, FA, IP, ChiP Llama VHH

Human Antibody

CAT Product Name Application Type
TAB-011CT Human Anti-HSP90B1 Recombinant Antibody (TAB-011CT) FC Human IgG1, κ
TAB-011CT-S(P) Human Anti-HSP90B1 Recombinant Antibody; scFv Fragment (TAB-011CT-S(P)) WB Human scFv
TAB-011CT-F(E) Human Anti-HSP90B1 Recombinant Antibody; Fab Fragment (TAB-011CT-F(E)) WB Human Fab

Recombinant Antibody

CAT Product Name Application Type
MOB-2448MZ Recombinant Mouse Anti-Human HSP90B1 Antibody (clone 3I4) ELISA, ICC/IF, WB Mouse antibody
MRO-0701-CN Mouse Anti-HSP90B1 Recombinant Antibody (clone F1-D10-G3) WB, IHC, IF Mouse IgM
MRO-1913-CN Rabbit Anti-HSP90B1 Polyclonal Antibody (MRO-1913-CN) WB, IF, IHC Rabbit IgG
VS-0923-FY75 Recombinant Mouse Anti-HSP90B1 Antibody (VS-0923-FY75) ELISA, WB Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1691 Rabbit Anti-HSP90B1 Recombinant Antibody (clone DS1691AB) ICC, IHC-P, WB Rabbit IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-LC4334 PE-Mamu-B*001:01/Human HSP90B1 (SDYLELDTI) MHC Tetramer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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