This product is a recombinant Human antibody that can recognize IAV HA. 3E1 exhibited broad neutralizing activity against H1 and H5 subtype viruses in vitro and protected mice against H1N1 and H5N6 viruses in vivo by inhibiting the low pH-induced HA conformational rearrangement, hence blocking membrane fusion.
Figure 1 In vitro binding of 3E1 mAb.
Binding affinity (Kd) of 3E1 mAb to the HAs of various strains of H1, H5 and H3 subtype IAVs. Data represent a representative experiment from three independent experiments.
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.
Figure 2 In vitro neutralization activity of 3E1 mAb.
In vitro microneutralization (IC₅₀) of 3E1 mAb against various strains of H1, H5 and H3 subtype IAVs. Graphs used for IC₅₀ values determined by averaging neutralization titre of three independent experiments.
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.
Figure 3 Prophylactic and therapeutic efficacy of 3E1 mAb in mice.
Prophylactic efficacy of 3E1 mAb against a lethal challenge with the A/Sichuan/09/2009(H1N1) virus.
Wang, W., Sun, X., Li, Y., Su, J., Ling, Z., Zhang, T., ... & Sun, B. (2016). Human antibody 3E1 targets the HA stem region of H1N1 and H5N6 influenza A viruses. Nature communications, 7, 13577.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NABG-078 | Recombinant Anti-IAV HA VHH Single Domain Antibody | FC, CA, IP, FuncS | Llama VHH |
HPAB-0344CQ | Recombinant Llama Anti-IAV HA Single Domain Antibody (SD38) | ELISA, Neut | Llama VHH |
HPAB-0345CQ | Recombinant Llama Anti-IAV HA Single Domain Antibody (SD36) | ELISA, Neut | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-H33 | Anti-IAV HA Recombinant Antibody (Firivumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
TAB-027ML | Anti-IAV HA Recombinant Antibody (Gedivumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
TAB-438CQ | Anti-IAV HA Recombinant Antibody (Navivumab) | ELISA, IHC, FC, IP, IF, BL | IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-077 | Recombinant Mouse Anti-IAV HA Antibody Fab Fragment (BH151) | Neut | IgG |
PFBW-077 | Recombinant Mouse Anti-IAV HA Antibody Fab Fragment (HC19) | Neut | IgG |
FAMAB-0190CQ-F(E) | Recombinant Mouse Anti-IAV HA Antibody Fab Fragment (FluBI) | ELISA, FC, Neut | Mouse Fab |
FAMAB-0191CQ-F(E) | Recombinant Mouse Anti-IAV HA Antibody Fab Fragment (λαPR8-1) | ELISA | Mouse Fab |
FAMAB-0192CQ-F(E) | Recombinant Mouse Anti-IAV HA Antibody Fab Fragment (λαPR8-9) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0652CQ | Recombinant Mouse Anti-IAV HA Antibody (pSAN13.4.1) | ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0680-CN | Human Anti-IAV HA Recombinant Antibody (HPAB-0680-CN) | ELISA, Neut | Human IgG |
HPAB-0681-CN | Human Anti-IAV HA Recombinant Antibody (HPAB-0681-CN) | ELISA, Neut | Human IgG |
HPAB-0682-CN | Human Anti-IAV HA Recombinant Antibody (HPAB-0682-CN) | ELISA, Neut | Human IgG |
HPAB-0019-WJ | Human Anti-IAV HA Recombinant Antibody (HPAB-0019-WJ) | ELISA, Neut | Human IgG |
PABC-488 | Recombinant Human Anti-IAV HA Antibody (27F3) | ELISA, Neut | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-027ML | Afuco™ Anti-IAV HA ADCC Recombinant Antibody (Gedivumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-438CQ | Afuco™ Anti-IAV HA ADCC Recombinant Antibody (Navivumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, BL | ADCC enhanced antibody |
AFC-TAB-H33 | Afuco™ Anti-IAV HA ADCC Recombinant Antibody (Firivumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0142-WJ-S(P) | Mouse Anti-IAV HA Recombinant Antibody; scFv Fragment (HPAB-0142-WJ-S(P)) | ELISA | Mouse scFv |
FAMAB-0204WJ-S(P) | Mouse Anti-IAV HA Recombinant Antibody (clone H5.16); scFv Fragment | ELISA, WB, Neut | Mouse scFv |
FAMAB-0205WJ-S(P) | Mouse Anti-IAV HA Recombinant Antibody (clone H5.22); scFv Fragment | ELISA, WB, Neut | Mouse scFv |
FAMAB-0206WJ-S(P) | Mouse Anti-IAV HA Recombinant Antibody (clone H5.24); scFv Fragment | ELISA, WB, Neut | Mouse scFv |
PABJ-0204-S(P) | Human Anti-IAV HA Recombinant Antibody (clone FluA-20); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YC213 | H-2Kd/Influenza A virus Haemagglutinin (IYSTVASSL) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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