Provided are anti-IgE antibodies that bind to the M1′ segment of a human IgE. The antibody can be used in treating and preventing IgE-mediated disorders, as well as kits comprising the anti-IgE antibodies.
Figure 1 shows the ability of humanized anti-IgE/M1′ antibody 47H4 v5 wt and afucosylted variant to induce ADCC.
While the wt and afuscosylated variants induce similar maximal cytotoxicity, the afucosylated variant ("AF") was more potent than the wildtype form (EC50 AF≈0.83 nM, EC50 wt≈6.6 nM).
Figure 2A-C show that serum IgE was reduced by 79%, and that IgE-producing plasma cells were reduced by 75%.
Figure 3E show no reduction in levels of other serum immunoglobulins.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-034ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (CMAB007) | ELISA | Humanized antibody |
TAB-049ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (IGE009) | ELISA, Inhib, FC | Humanized antibody |
TAB-050ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (IGE026) | ELISA, Inhib, FC | Humanized antibody |
TAB-034ZJ-F(E) | Anti-Human IgE Recombinant Antibody Fab Fragment (CMAB007) | ELISA | Humanized antibody |
TAB-049ZJ-F(E) | Anti-Human IgE Recombinant Antibody Fab Fragment (IGE009) | ELISA, Inhib, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-095ZJ | Anti-Human IgE Therapeutic Single Domain Antibody (39D11) | ELISA, Inhib, FC | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-009LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-010LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-011LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-009LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-010LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-011LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-156LC | Recombinant Anti-Human IgE Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-156LC-1 | Recombinant Anti-Human IgE Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0208CQ | Mouse Anti-IgE Recombinant Antibody (clone TES-C21) | ELISA, Block, FuncS | Mouse IgG1 |
HPAB-0209CQ | Human Anti-IgE Recombinant Antibody (clone huTES-C21) | ELISA, Block | Humanized IgG1 |
HPAB-AP102-YC | Mouse Anti-IgE Recombinant Antibody (clone 47H4) | ELISA | Mouse IgG |
HPAB-AP103-YC | Mouse Anti-IgE Recombinant Antibody (clone 7A6) | WB, FuncS, ELISA | Mouse IgG |
HPAB-AP104-YC | Mouse Anti-IgE Recombinant Antibody (clone 26A11) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-N0143-YC-S(P) | Human Anti-IgE Recombinant Antibody (clone hu4F11-12); scFv Fragment | ELISA, Inhib | Humanized scFv |
HPAB-0283-YJ-S(P) | Mouse Anti-IgE Recombinant Antibody; scFv Fragment (HPAB-0283-YJ-S(P)) | ELISA, Enzymatic activity | Mouse scFv |
HPAB-1195-FY-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-1195-FY-F(E)) | ELISA | Human Fab |
HPAB-1196-FY-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-1196-FY-F(E)) | ELISA | Human Fab |
HPAB-1197-FY-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-1197-FY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP674-YC-F(E) | Human Anti-IgE Recombinant Antibody (clone Omaizumab S267E/L328F); Fab Fragment | ELISA, FuncS | Humanized Fab |
HPAB-AP675-YC-F(E) | Human Anti-IgE Recombinant Antibody (clone MaE11-H1L1); Fab Fragment | ELISA, FuncS | Humanized Fab |
HPAB-AP676-YC-F(E) | Human Anti-IgE Recombinant Antibody (clone MaE11-H1L1 S267E/L328F); Fab Fragment | ELISA, FuncS | Humanized Fab |
HPAB-AP677-YC-F(E) | Human Anti-IgE Recombinant Antibody (clone MaE11-H1L1 G236R/L328F); Fab Fragment | ELISA, FuncS | Humanized Fab |
HPAB-AP678-YC-F(E) | Mouse Anti-IgE Recombinant Antibody (clone MaE11); Fab Fragment | ELISA, Inhib | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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