Provided are anti-IgE antibodies that bind to the M1′ segment of a human IgE. The antibody can be used in treating and preventing IgE-mediated disorders, as well as kits comprising the anti-IgE antibodies.
Figure 1 shows the results of application of M1′ antibodies of the epitope group A2, including 1C11, 26A11, 51D2, 45C1) and epitope group B/C, including 26B11 and 28E9 without crosslinking.
Figure 2 shows IgE levels over time in response to NB infection with anti-IgE/M1′ and control antibodies.
Figure 3 show that anti-IgE/M1′ reduced serum IgE levels by 82-89% within four days of treatment.
Figure 4 show that anti-IgE/M1′ reduced serum IgE levels by 82-89% within four days of treatment.
Figure 5 illustrate the ability of the anti-IgE/M1′antibodies to therapeutically treat IgE response occurring late in an infection cycle to Nippostrongylus brasiliensis (“NB”) infection.
Figure 5A shows that peak IgE production occurred around day 15 and that all anti-IgE/M1′ antibodies reduced serum IgE. Figure 5B-5C shows that anti-IgE/M1′ antibody shows a significant reduction in both absolute and normalized IgE levels, respectively, relative to commencement of treatment.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-049ZJ | Anti-Human IgE Recombinant Antibody (IGE009) | ELISA, Inhib, FC | Humanized antibody |
TAB-050ZJ | Anti-Human IgE Recombinant Antibody (IGE026) | ELISA, Inhib, FC | Humanized antibody |
TAB-034ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (CMAB007) | ELISA | Humanized antibody |
TAB-049ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (IGE009) | ELISA, Inhib, FC | Humanized antibody |
TAB-050ZJ-S(P) | Anti-Human IgE Recombinant Antibody scFv Fragment (IGE026) | ELISA, Inhib, FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-095ZJ | Anti-Human IgE Therapeutic Single Domain Antibody (TAB-095ZJ) | ELISA, Inhib, FC | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-009LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-010LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-011LC | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-009LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-010LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-011LC-1 | Recombinant Anti-Human IgE Antibody (Fab glycosylation/Fc glycosylation) | ELISA, IP | Human antibody |
Gly-156LC | Recombinant Anti-Human IgE Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-156LC-1 | Recombinant Anti-Human IgE Antibody (Fc glycosylation/Non fucosylated) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0126-FY-S(P) | Human Anti-IgE Recombinant Antibody (clone 2E19); scFv Fragment | FC | Humanized scFv |
HPAB-0209CQ-S(P) | Human Anti-IgE Recombinant Antibody (clone huTES-C21); scFv Fragment | ELISA, Block | Humanized scFv |
HPAB-0043-WJ-S(P) | Mouse Anti-IgE Recombinant Antibody; scFv Fragment (HPAB-0043-WJ-S(P)) | ELISA, WB | Mouse scFv |
HPAB-AP369-YC-S(P) | Mouse Anti-IgE Recombinant Antibody; scFv Fragment (HPAB-AP369-YC-S(P)) | FC, Apop | Mouse scFv |
HPAB-AP674-YC-S(P) | Human Anti-IgE Recombinant Antibody (clone Omaizumab S267E/L328F); scFv Fragment | ELISA, FuncS | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0043-WJ-F(E) | Mouse Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0043-WJ-F(E)) | ELISA, WB | Mouse Fab |
HPAB-N0143-YC-F(E) | Human Anti-IgE Recombinant Antibody (clone hu4F11-12); Fab Fragment | ELISA, Inhib | Humanized Fab |
HPAB-0519-WJ-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0519-WJ-F(E)) | ELISA | Human Fab |
HPAB-0520-WJ-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0520-WJ-F(E)) | ELISA | Human Fab |
HPAB-0521-WJ-F(E) | Human Anti-IgE Recombinant Antibody; Fab Fragment (HPAB-0521-WJ-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP102-YC | Mouse Anti-IgE Recombinant Antibody (clone 47H4) | ELISA | Mouse IgG |
HPAB-AP103-YC | Mouse Anti-IgE Recombinant Antibody (clone 7A6) | WB, FuncS, ELISA | Mouse IgG |
HPAB-AP104-YC | Mouse Anti-IgE Recombinant Antibody (clone 26A11) | ELISA | Mouse IgG |
HPAB-AP105-YC | Human Anti-IgE Recombinant Antibody (clone 47H4v5) | ELISA | Human IgG |
HPAB-AP369-YC | Mouse Anti-IgE Recombinant Antibody (HPAB-AP369-YC) | FC, Apop | Mouse IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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