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  • Rabbit Anti-IGF2R Recombinant Antibody (VS3-CJ597)

Rabbit Anti-IGF2R Recombinant Antibody (VS3-CJ597) (CAT#: VS3-CJ597)

This product is a rabbit antibody that recognizes human, mouse, and rat IGF2R.


See more Engineered Antibody products for IGF2R
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Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11332/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9661/210_F2_2_selected.jpg
Normal Tissue
Figure 3 IHC staining of human parathyroid gland
Figure 3 IHC staining of human parathyroid gland
(Immunohistochemical staining of human parathyroid gland shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/9661/ihc_selected.jpg
Figure 4 Placenta
Figure 4 Placenta
(Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11332/29188_A_1_7.jpg
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11332/29188_B_7_5.jpg
Figure 6 Colon
Figure 6 Colon
(Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11332/29188_A_7_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11332/29188_A_8_4.jpg
Figure 8 Testis
Figure 8 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/11332/29188_A_6_6.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197081-IGF2R

Specifications

  • Immunogen
  • Recombinant protein
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse, Rat IGF2R
  • Species Reactivity
  • Human, Mouse, Rat
  • Applications
  • WB, ICC, IF, IHC, IP, FC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Protein A affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 40% Glycerol, 1% BSA, TBS, pH7.4.
  • Preservative
  • 0.05% Sodium Azide
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Flow Cytometry.

Target

  • Alternative Names
  • MPR1; MPRI; CD222; CIMPR; M6P-R; MPR300; CI-M6PR; MPR 300; M6P/IGF2R
  • Sequence Similarities
  • Belongs to the MRL1/IGF2R family.
  • Cellular Localization
  • Endosome, Golgi apparatus, Membrane
  • Post Translation Modifications
  • Palmitoylated (PubMed:18817523).
    Undergoes cysteine S-palmitoylation which promotes interaction with the retromer cargo-selective complex which mediates its retrograde trafficking to the Golgi apparatus (PubMed:18817523).
  • Function
  • Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523).
    Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523).
    The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523).
    This receptor also binds IGF2 (PubMed:18046459).
    Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005).

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "IGF2R"

Recombinant Antibody

CAT Product Name Application Type
MOB-1759z Mouse Anti-IGF2R Recombinant Antibody (clone 23A11) WB, FC, ICC, IF, IHC, IP Mouse IgG2a
MOB-1165CT Recombinant Mouse anti-Human IGF2R Monoclonal antibody (NFN-349) FC
MRO-1958-CN Rabbit Anti-IGF2R Polyclonal Antibody (MRO-1958-CN) IF, IHC, FC Rabbit IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-1084CQ Mouse Anti-IGF2R Recombinant Antibody (clone 2G11) Block, FC, ICC, IF, IHC, IP, WB Mouse IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1759 Rabbit Anti-IGF2R Recombinant Antibody (clone DS1759AB) WB, IHC, ICC, IP, FC Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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