This product is a recombinant antibody that recognizes IL13. The monoclonal antibody mAb13.2 reacts with the epitope of IL13. Fully Humanized mAb13.2 Neutralizes IL-13-Associated Activities In Vitro.
Figure 1 Cynomolgus monkey IL-13 has bioactivity and can be neutralized with antibodies.
A half-maximal concentration of human (open symbols) or NHP (solid symbols) IL-13 was combined with the indicated concentration of mAb13.2.
Figure 2 Anti–IL-13 antibody reduced total BAL inflammation in response to A suum challenge.
Animals were given IVIG or saline (control), dexamethasone (DEX), or anti–IL-13 (mAb13.2 or IMA-638). Total cells.
Bree, A., Schlerman, F. J., Wadanoli, M., Tchistiakova, L., Marquette, K., Tan, X. Y., ... & Vunnum, S. (2007). IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. Journal of Allergy and Clinical Immunology, 119(5), 1251-1257.
Figure 3 Anti–IL-13 antibody reduced total BAL inflammation in response to A suum challenge.
Animals were given IVIG or saline (control), dexamethasone (DEX), or anti–IL-13 (mAb13.2 or IMA-638). Neutrophils.
Bree, A., Schlerman, F. J., Wadanoli, M., Tchistiakova, L., Marquette, K., Tan, X. Y., ... & Vunnum, S. (2007). IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys. Journal of Allergy and Clinical Immunology, 119(5), 1251-1257.
Figure 4 Serum concentration of anti–IL-13 Ab in human doseranging studies.
Serum concentrations of IMA-638 or IMA-026 were determined by ELISA.
Kasaian, M. T., Raible, D., Marquette, K., Cook, T. A., Zhou, S., Tan, X. Y., & Tchistiakova, L. (2011). IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2. The Journal of Immunology, 187(1), 561-569.
Figure 5 Anti–IL-13 Abs differentially affect IL-13 internalization.
Assays were developed to detect IL-13 in the presence or absence of anti-IL-13 Abs: IMA-026. The extracellular medium was collected and assayed for IL-13 using ELISAs developed to detect the cytokine in the presence of anti–IL-13 Ab.
Kasaian, M. T., Raible, D., Marquette, K., Cook, T. A., Zhou, S., Tan, X. Y., & Tchistiakova, L. (2011). IL-13 antibodies influence IL-13 clearance in humans by modulating scavenger activity of IL-13Rα2. The Journal of Immunology, 187(1), 561-569.
Figure 6 Surface plasmon resonance (Biacore) analysis of human or sheep IL-13 binding to immobilized sIL-13R or IMA-638.
Human IL-13 binding to IMA-638.
Kasaian, M. T., Donaldson, D. D., Tchistiakova, L., Marquette, K., Tan, X. Y., Ahmed, A., ... & Barry, A. B. (2007). Efficacy of IL-13 neutralization in a sheep model of experimental asthma. American journal of respiratory cell and molecular biology, 36(3), 368-376.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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