Rabbit Anti-ISL1 Recombinant Antibody (VS3-CJ1077) (CAT#: VS3-CJ1077)
This product is a rabbit antibody that recognizes human, and mouse ISL1.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SH-SY5Y
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48613/1792_G11_2_selected.jpg
(Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & mitochondria.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48613/1792_G11_2_selected.jpg
Figure 2 IHC staining of human caudate
(Immunohistochemical staining of human caudate shows strong nuclear positivity in a subset of glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/ihc_selected.jpg
(Immunohistochemical staining of human caudate shows strong nuclear positivity in a subset of glial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/ihc_selected.jpg
Figure 3 Cerebral cortex
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_B_7_5.jpg
(Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_B_7_5.jpg
Figure 4 Caudate
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_B_7_7.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_B_7_7.jpg
Figure 5 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_A_7_4.jpg
Figure 6 Kidney
(Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_A_7_5.jpg
(Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_A_7_5.jpg
Figure 7 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_A_5_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57416/132766_A_5_6.jpg
Figure 8 RNA cell line category: Cell line enriched (SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000016082-ISL1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000016082-ISL1
Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse ISL1
- Species Reactivity
- Human, Mouse
- Applications
- WB, ICC, IF, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation.
Target
- Alternative Names
- Isl-1; ISLET1
- Gene ID
- 3670
- UniProt ID
- P61371
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated.
- Protein Refseq
- NP_002193.2
- Function
- DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ISL1"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1009MZ | Recombinant Mouse Anti-Human ISL1 Antibody (clone 2C2) | ELISA, WB sELISA | Mouse antibody |
| MRO-0875-CN | Recombinant Rabbit Anti-ISL1 Monoclonal Antibody (CBACN-327) | WB, IF, IP | Rabbit IgG |
| ZG-0772J | Rabbit Anti-ISL1 Recombinant Antibody (clone 4F6) | ELISA, WB | Rabbit IgG |
| VS3-QX605 | Mouse Anti-ISL1 Recombinant Antibody (clone 1H9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-XY886 | Mouse Anti-ISL1 Recombinant Antibody (clone 1B1) | ELISA, WB, ICC | Mouse IgG2b |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1868 | Hi-Affi™ Recombinant Rabbit Anti-ISL1 Monoclonal Antibody (DS1868AB) | WB, IP, ICC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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