Mouse Anti-ITGAL Recombinant Antibody (clone Cris-3) (CAT#: VS3-CJ773)
This product is a mouse antibody that recognizes human ITGAL (CD11a).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Bone marrow
(Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_B_5_4.jpg
(Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_B_5_4.jpg
Figure 2 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_A_9_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25011/57823_A_9_8.jpg
Figure 3 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005844-ITGAL
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005844-ITGAL
Figure 3 RNA cell line category: Cell line enriched (HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005844-ITGAL
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000005844-ITGAL
Specifications
- Immunogen
- Native purified human CD11a
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human ITGAL (CD11a)
- Species Reactivity
- Human
- Clone
- Cris-3
- Applications
- IF, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS, pH 7.3.
- Preservative
- 0.02% Sodium Azide
- Storage
- Store at 4°C for one year. Do not freeze.
- Shipping
- Shipped at 4°C
Applications
- Application Notes
- This antibody has been tested for use in Immunofluorescence, Flow Cytometry.
Target
- Alternative Names
- CD11A; LFA-1; LFA1A
- Gene ID
- 3683
- UniProt ID
- P20701
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
- Protein Refseq
- NP_001107852.1; NP_002200.2
- Function
- Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "ITGAL"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-024 | Anti-Human CD11A Recombinant Antibody (Efalizumab) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-108 | Anti-Human CD11a Recombinant Antibody (Odulimomab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG1 |
| TAB-459CL | Mouse Anti-ITGAL Recombinant Antibody (TAB-459CL) | ELISA | Mouse IgG |
| TAB-1579CL | Rat Anti-ITGAL Recombinant Antibody (TAB-1579CL) | Block | Rat IgG2a, κ |
| TAB-1579CL-S(P) | Rat Anti-ITGAL Recombinant Antibody; scFv Fragment (TAB-1579CL-S(P)) | Block | Rat scFv |
| TAB-1579CL-F(E) | Rat Anti-ITGAL Recombinant Antibody; Fab Fragment (TAB-1579CL-F(E)) | Block | Rat Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57) | WB | Human IgG |
| MOB-008CQ | Rat Anti-Mouse ITGAL Antibody (M17/4), Alexa Fluor® 647 | FC, IHC, IP | Rat IgG2a, κ |
| FAMAB-1185CQ | Mouse Anti-ITGAL Recombinant Antibody (clone YTH 81.5) | FC | Mouse IgG1 |
| VS3-CJ774 | Rabbit Anti-ITGAL Recombinant Antibody (VS3-CJ774) | WB, ICC, IF, IHC, IP, FC | Rabbit IgG |
| VS4-WK256 | Rabbit Anti-ITGAL Recombinant Antibody (clone 2B2) | ELISA, WB, IF | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); Fab Fragment | WB | Human Fab |
| NS-018CN-F(E) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); Fab Fragment | FC, ELISA | Human Fab |
| HPAB-0487-WJ-F(E) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); Fab Fragment | ELISA | Mouse Fab |
| HPAB-S0088-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); Fab Fragment | Inhib | Chimeric (mouse/human) Fab |
| HPAB-S0089-YC-F(E) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); Fab Fragment | Inhib | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBW-159 | Human Anti-ITGAL Recombinant Antibody (clone AL-57); scFv Fragment | WB | Human scFv |
| NS-018CN-S(P) | Human Anti-ITGAL Recombinant Antibody (clone MHM24); scFv Fragment | FC, ELISA | Human scFv |
| HPAB-0487-WJ-S(P) | Mouse Anti-ITGAL Recombinant Antibody (clone S6F1); scFv Fragment | ELISA | Mouse scFv |
| HPAB-S0088-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone chMHM24); scFv Fragment | Inhib | Mouse scFv |
| HPAB-S0089-YC-S(P) | Human Anti-ITGAL Recombinant Antibody (clone huMHM24); scFv Fragment | Inhib | Humanized scFv |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-755LC | Anti-human ITGAL Recombinant Antibody (Chimeric S6F1) (TAB-755LC) | ELISA | Chimeric antibody (mouse/human) |
| TAB-755LC-S(P) | Anti-human ITGAL scFv Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
| TAB-755LC-F(E) | Anti-human ITGAL Fab Fragment (Chimeric S6F1) | ELISA | Chimeric antibody (mouse/human) |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1559CQ | Recombinant Mouse Anti-ITGAL Antibody (38) | FC, ICC/IF, IHC-Fr, IP, Neut | IgG2a |
| NEUT-1563CQ | Recombinant Mouse Anti-ITGAL Antibody (CBL227) | FC, IHC, IP, Neut | IgG2a |
| NEUT-1565CQ | Recombinant Rat Anti-Itgal Antibody (121/7) | FC, IP, Neut, WB | IgG2a |
| NEUT-1568CQ | Recombinant Rat Anti-Itgal Antibody (I21/7) | Neut, FC, IHC, IHC-Fr, IP, ICC | IgG2a, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1560CQ | Recombinant Mouse Anti-ITGAL Antibody (HI111) | FC, BL | IgG1, κ |
| NEUT-1561CQ | Recombinant Mouse Anti-ITGAL Antibody (MEM-83) | BL, FC, FuncS, IP | IgG1 |
| NEUT-1562CQ | Recombinant Mouse Anti-ITGAL Antibody (TS-1/22.1.1.13) | BL, FC | IgG1 |
| NEUT-1564CQ | Recombinant Mouse Anti-ITGAL Antibody (R7-1) | BL, FC | IgG1 |
| NEUT-1566CQ | Recombinant Rat Anti-Itgal Antibody (M17/4) | IP, IHC-Fr, FuncS, FC, BL | IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1878 | Hi-Affi™ Recombinant Rabbit Anti-ITGAL Monoclonal Antibody (DS1878AB) | BL, FC, ICC/IF, IHC-P, IP, WB | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-018CN | Human Anti-ITGAL Recombinant Antibody (clone MHM24) | FC, ELISA, Inhib, FuncS | Human IgG1 |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-108 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody (Odulimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-024 | Afuco™ Anti-ITGAL ADCC Recombinant Antibody (Efalizumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0066SW | Recombinant Llama Anti-ITGAL Single Domain Antibody (138-B10) | ELISA, WB | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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