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  • Mouse Anti-ITGB1 Recombinant Antibody (clone TS2/16.2.1)

Mouse Anti-ITGB1 Recombinant Antibody (clone TS2/16.2.1) (CAT#: VS3-CJ417)

This product is a mouse antibody that recognizes human ITGB1 (CD29).


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Subcellular Location
Figure 1 IF staining of human cell line BJ
Figure 1 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3434/if_selected.jpg
Figure 2 IF staining of human cell line BJ
Figure 2 IF staining of human cell line BJ
(Immunohistochemical staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69003/165766_B_5_7_selected.jpg
Normal Tissue
Figure 3 Immunofluorescent staining of human cell line BJ
Figure 3 Immunofluorescent staining of human cell line BJ
(Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/3434/ihc_selected.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59297/139504_A_7_5.jpg
Figure 5 Smooth muscle
Figure 5 Smooth muscle
(Smooth muscle cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59297/139504_B_6_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1)
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000150093-ITGB1
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1)
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000150093-ITGB1

Specifications

  • Immunogen
  • Native purified human CD29
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1
  • Specificity
  • Human ITGB1 (CD29)
  • Species Reactivity
  • Human
  • Clone
  • TS2/16.2.1
  • Applications
  • IF, FC
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity chromatography
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • PBS, pH 7.3.
  • Preservative
  • 0.02% Sodium Azide
  • Storage
  • Store at 4°C for one year. Do not freeze.
  • Shipping
  • Shipped at 4°C

Applications

  • Application Notes
  • This antibody has been tested for use in Immunofluorescence, Flow Cytometry.

Target

  • Alternative Names
  • CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
  • Sequence Similarities
  • Belongs to the integrin beta chain family.
  • Cellular Localization
  • Cell junction, Cell membrane, Cell projection, Endosome, Membrane
  • Post Translation Modifications
  • The cysteine residues are involved in intrachain disulfide bonds.
  • Function
  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
    Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099).
    ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
    ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
    ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
    ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
    Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity).

Recommended Products

Isotype Control

Secondary Antibody

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ITGB1"

Mouse Antibody

CAT Product Name Application Type
TAB-772LC Anti-human ITGB1 Recombinant Antibody (1B4) (TAB-772LC) FuncS
TAB-772LC-S(P) Anti-human ITGB1 scFv Fragment (1B4) ELISA
TAB-772LC-F(E) Anti-human ITGB1 Fab Fragment (1B4) ELISA

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0277MZ Chicken Anti-Integrin β1 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-1585CQ Recombinant Mouse Anti-ITGB1 Antibody (CBL252) FC, ELISA, WB, IP, FuncS, Inhib IgG1
NEUT-1587CQ Recombinant Mouse Anti-ITGB1 Antibody (P5D2) BL, FC, IP, CyTOF, ICC IgG1
NEUT-1588CQ Recombinant Armenian Hamster Anti-Itgb1 Antibody (HMβ1-1) FC, IP, BL, IHC IgG

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1586CQ Recombinant Mouse Anti-ITGB1 Antibody (P4C10) WB, Neut, ELISA, FC, ICC/IF, IHC-Fr, IP IgG1
NEUT-1589CQ Recombinant Armenian hamster Anti-Itgb1 Antibody (HMb1-1) FC, FuncS, Neut IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1882 Hi-Affi™ Recombinant Rabbit Anti-ITGB1 Monoclonal Antibody (DS1882AB) WB IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-047CN Human Anti-ITGB1 Recombinant Antibody ELISA, WB, IHC Human IgG

Fab Fragment Antibody

CAT Product Name Application Type
NS-047CN-F(E) Human Anti-ITGB1 Recombinant Antibody; Fab Fragment ELISA, WB, IHC Human Fab
HPAB-0253CQ-F(E) Mouse Anti-ITGB1 Recombinant Antibody (clone HUTS-21); Fab Fragment FC Mouse Fab
HPAB-0254CQ-F(E) Rat Anti-ITGB1 Recombinant Antibody (clone MAb AIIB2); Fab Fragment ELISA, FC, WB, ICC, Block, IP, IHC Rat Fab

scFv Fragment Antibody

CAT Product Name Application Type
NS-047CN-S(P) Human Anti-ITGB1 Recombinant Antibody; scFv Fragment ELISA, WB, IHC Human scFv

Recombinant Antibody

CAT Product Name Application Type
HPAB-0253CQ Mouse Anti-ITGB1 Recombinant Antibody (clone HUTS-21) FC Mouse IgG2a, κ
HPAB-0254CQ Rat Anti-ITGB1 Recombinant Antibody (clone MAb AIIB2) ELISA, FC, WB, ICC, Block, IP, IF, IHC Rat IgG1, κ
ZG-0971F Mouse Anti-ITGB1 Recombinant Antibody (clone 1G2) ICC, IHC-Fr, WB Mouse IgG2a
ZG-0978F Mouse Anti-ITGB1 Recombinant Antibody (clone 2B1) ICC, IHC-Fr, WB Mouse IgG1
ZG-0776J Rabbit Anti-ITGB1 Recombinant Antibody (clone 32A10) ELISA, WB, IHC, IF, FC Rabbit IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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