Human Anti-KRT17 Recombinant Antibody (clone A4) (CAT#: FAMAB-0260JF)
Recombinant monoclonal antibody specially binds to keratin 17 (KRT17). This human anti-KRT17 antibody (A4) can be widely used in treatment of patients with epidermal proliferative dermatoses, especially psoriasis.
Specific Inquiry
WB
Figure 1 Western blot analysis using proteins from human gastric adenocarcinoma tissues shows KRT17 protein expression in tumor samples of various stages.
Knockdown of KRT17 mRNA and protein expression in gastric adenocarcinoma cell lines.
Chivu-Economescu, M., Dragu, D. L., Necula, L. G., Matei, L., Enciu, A. M., Bleotu, C., & Diaconu, C. C. (2017). Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells. Gastric Cancer, 20(6), 948-959.
Inhib
Figure 2 Downregulation of KRT17 inhibits cancer cell proliferation on AGS and NCI-N87 cell lines.
Cell proliferation was determined using CellTiter96 assay and recording absorbance at 550 nm with a spectrophotometric plate reader.
Chivu-Economescu, M., Dragu, D. L., Necula, L. G., Matei, L., Enciu, A. M., Bleotu, C., & Diaconu, C. C. (2017). Knockdown of KRT17 by siRNA induces antitumoral effects on gastric cancer cells. Gastric Cancer, 20(6), 948-959.
IHC
Figure 3 Expression of KRT17 in conventional RCC.
Strong KRT17 expression in single tumor cells.
Sarlos, D. P., Yusenko, M. V., Peterfi, L., Szanto, A., & Kovacs, G. (2019). Dual role of KRT17: development of papillary renal cell tumor and progression of conventional renal cell carcinoma. Journal of Cancer, 10(21), 5124.
FC
Figure 4 Effect of Krt17 on the cell cycle and apoptosis in GC cells.
Downregulation of Krt17 significantly increased apoptosis in SGC-7901 cells.
Hu, H., Xu, D. H., Huang, X. X., Zhu, C. C., Xu, J., Zhang, Z. Z., & Zhao, G. (2018). Keratin17 promotes tumor growth and is associated with poor prognosis in gastric cancer. Journal of Cancer, 9(2), 346.
Specifications
- Host Species
- Human
- Derivation
- Human phage display Fab library
- Type
- Human IgG
- Specificity
- Human KRT17
- Species Reactivity
- Human
- Clone
- A4
- Applications
- WB, Inhib, IHC, FC
- Related Disease
- Psoriasis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The KRT17 antibody has been reported in applications of Western Blot, Inhibition, Immunohistochemistry, Flow Cytometry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1985z | Mouse Anti-KRT17 Recombinant Antibody (clone 42C7) | WB, FC, ICC, IF, IHC | Mouse IgG2b, κ |
| MOB-1242MZ | Recombinant Mouse Anti-Human KRT17 Antibody (clone Lt28.F4) | ICC/IF, IHC-Fr, IHC-P, WB | Mouse antibody |
| ZG-0239J | Mouse Anti-KRT17 Recombinant Antibody (ZG-0239J) | IHC-P, IF | Mouse IgG |
| ZG-0240J | Mouse Anti-KRT17 Recombinant Antibody (ZG-0240J) | IHC-P, IF | Mouse IgG |
| ZG-0322U | Rabbit Anti-KRT17 Recombinant Antibody (clone V21-R) | IHC-P | Rabbit IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1981 | Hi-Affi™ Recombinant Rabbit Anti-KRT17 Monoclonal Antibody (DS1981AB) | ICC/IF, IHC-P, IP, WB | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0153-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D1-1B2); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0154-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-5C); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0155-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-9D); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-J0156-YC-S(P) | Human Anti-KRT17 Recombinant Antibody (clone D3-12F); scFv Fragment | ELISA, FC | Human scFv |
| FAMAB-0260JF-S(P) | Human Anti-KRT17 Recombinant Antibody (clone A4); scFv Fragment | IHC, WB, ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0156-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-12F); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0157-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-6G); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0158-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D3-12E); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-J0159-YC-F(E) | Human Anti-KRT17 Recombinant Antibody (clone D1-1F); Fab Fragment | ELISA, FC | Human Fab |
| FAMAB-0260JF-F(E) | Human Anti-KRT17 Recombinant Antibody (clone A4); Fab Fragment | IHC, WB, ELISA, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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