Recombinant Human Anti-MERS-CoV RBD Antibody (CDC2-C2) (CAT#: PABC-273)
This product is a recombinant Human antibody that can recognize MERS-CoV RBD. The antibody can specifically bind to MERS England1 RBD and neutralize MERS-CoV infection.
Specific Inquiry
Neut
Figure 1 MAb neutralization breadth.
S1-specific MAbs (in blue) were measured for neutralization activity against 8 to 11 strains of MERS-CoV S-pseudotyped viruses as indicated, including strains identified from 2012 to 2015. Percent neutralization at the different MAb concentrations is shown. Data points represent the means of triplicate replicates with standard errors.
Wang, L., Shi, W., Chappell, J. D., Joyce, M. G., Zhang, Y., Kanekiyo, M., ... & Corbett, K. S. (2018). Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on the Middle East respiratory syndrome coronavirus spike glycoprotein to avoid neutralization escape. Journal of virology, 92(10), e02002-17.
Neut
Figure 1 Passive transfer of RBD-, S1-, and S2-specific neutralizing MAbs protect against MERS-CoV infection.
Survival curves of the different groups (6 hDPP4 mice per group). After challenge, hDPP4 mice were euthanized due to the severity of disease signs or at 28 dpi.
Wang, L., Shi, W., Chappell, J. D., Joyce, M. G., Zhang, Y., Kanekiyo, M., ... & Corbett, K. S. (2018). Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on the Middle East respiratory syndrome coronavirus spike glycoprotein to avoid neutralization escape. Journal of virology, 92(10), e02002-17.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- MERS-CoV RBD
- Species Reactivity
- HCoV-EMC
- Clone
- CDC2-C2
- Applications
- ELISA, Neut
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody CDC2-C2 has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Middle East respiratory syndrome coronavirus; MERS-CoV; Middle East respiratory syndrome coronavirus receptor binding domain in S protein; MERS-CoV RBD
- UniProt ID
- K9N5Q8
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone CDC2-C2"
See other products for "MERS-CoV RBD"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-882LC-S(P) | Mouse Anti-MERS-CoV RBD Recombinant Antibody; scFv Fragment (MRO-882LC-S(P)) | ELISA | Mouse scFv |
| MRO-883LC-S(P) | Mouse Anti-MERS-CoV RBD Recombinant Antibody; scFv Fragment (MRO-883LC-S(P)) | ELISA | Mouse scFv |
| MRO-882LC-F(E) | Mouse Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-882LC-F(E)) | ELISA | Mouse Fab |
| MRO-883LC-F(E) | Mouse Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-883LC-F(E)) | ELISA | Mouse Fab |
| MRO-898LC-F(E) | Anti-MERS-CoV RBD Recombinant Antibody Fab Fragment (4C2) | ELISA | Mouse antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-884LC-F(E) | Human Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-884LC-F(E)) | ELISA | Human Fab |
| MRO-885LC-F(E) | Human Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-885LC-F(E)) | ELISA | Human Fab |
| MRO-895LC-F(E) | Human Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-895LC-F(E)) | ELISA | Human Fab |
| MRO-896LC-F(E) | Human Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-896LC-F(E)) | ELISA | Human Fab |
| MRO-897LC-F(E) | Human Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (MRO-897LC-F(E)) | ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-272 | Monkey Anti-MERS-CoV RBD Recombinant Antibody (PABC-272) | ELISA, Neut | Monkey IgG |
| PABC-315 | Monkey Anti-MERS-CoV RBD Recombinant Antibody (PABC-315) | ELISA, Neut | Monkey IgG |
| PABC-370 | Recombinant Human Anti-MERS-CoV RBD Antibody (CBC-001) | Neut | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-272 | Monkey Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (PFBC-272) | ELISA, Neut | Monkey Fab |
| PFBC-273 | Recombinant Human Anti-MERS-CoV RBD Antibody Fab Fragment (CDC2-C2) | ELISA, Neut | Human Fab |
| PFBC-315 | Monkey Anti-MERS-CoV RBD Recombinant Antibody; Fab Fragment (PFBC-315) | ELISA, Neut | Monkey Fab |
| PFBC-370 | Recombinant Human Anti-MERS-CoV RBD Antibody Fab Fragment (CBC-001) | Neut | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-272 | Monkey Anti-MERS-CoV RBD Recombinant Antibody; scFv Fragment (PSBC-272) | ELISA, Neut | Monkey scFv |
| PSBC-273 | Recombinant Human Anti-MERS-CoV RBD Antibody scFv Fragment (CDC2-C2) | ELISA, Neut | Human scFv |
| PSBC-315 | Monkey Anti-MERS-CoV RBD Recombinant Antibody; scFv Fragment (PSBC-315) | ELISA, Neut | Monkey scFv |
| PSBC-370 | Recombinant Human Anti-MERS-CoV RBD Antibody scFv Fragment (CBC-001) | Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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