Recombinant Human Anti-MERS-CoV S Antibody (MCA1) (CAT#: PABC-274)
This product is a recombinant Human antibody that can recognize MERS-CoV S. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). This antibody is a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets.
Specific Inquiry
Neut
Figure 1 MCA1 neutralized Middle East respiratory syndrome coronavirus (MERS-CoV) in vitro.
The neutralizing activities of MCA1 against MERS-CoV were examined using Vero E6 cells. An irrelevant human immunoglobulin G (IgG) was used as a control.
Chen, Z., Bao, L., Chen, C., Zou, T., Xue, Y., Li, F., ... & Wang, J. (2017). Human neutralizing monoclonal antibody inhibition of Middle East respiratory syndrome coronavirus replication in the common marmoset. The Journal of infectious diseases, 215(12), 1807-1815.
FuncS
Figure 2 Prophylactic efficacy of MCA1 in common marmosets, which were intravenously inoculated with the antibody at doses of 5 mg/kg (designated G1) and 20 mg/kg (G2) and then challenged with Middle East respiratory syndrome coronavirus (MERS-CoV) 24 hours later.
A control group was simultaneously infected and set up as a model (M) group. All groups were monitored twice daily for 3 days. A, Clinical scores (n = 3 per group). B, Temperature changes (n = 3 per group). C, Mean body weight changes (n = 3 per group). Results are presented as means with standard deviations. *P < .05 (t test).
Chen, Z., Bao, L., Chen, C., Zou, T., Xue, Y., Li, F., ... & Wang, J. (2017). Human neutralizing monoclonal antibody inhibition of Middle East respiratory syndrome coronavirus replication in the common marmoset. The Journal of infectious diseases, 215(12), 1807-1815.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- MERS-CoV S
- Species Reactivity
- MERS-CoV
- Clone
- MCA1
- Applications
- ELISA, Neut, FuncS
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody MCA1 has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization, Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Middle East respiratory syndrome coronavirus; MERS-CoV; Middle East respiratory syndrome coronavirus S protein; MERS-CoV S
- UniProt ID
- K9N5Q8
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone MCA1"
See other products for "MERS-CoV S"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-880LC | Mouse Anti-MERS-CoV S Recombinant Antibody (MRO-880LC) | ELISA | Mouse antibody |
| MRO-881LC | Mouse Anti-MERS-CoV S Recombinant Antibody (MRO-881LC) | ELISA | Mouse antibody |
| MRO-880LC-S(P) | Mouse Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-880LC-S(P)) | ELISA | Mouse scFv |
| MRO-881LC-S(P) | Mouse Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (MRO-881LC-S(P)) | ELISA | Mouse scFv |
| MRO-880LC-F(E) | Mouse Anti-MERS-CoV S Recombinant Antibody; Fab Fragment (MRO-880LC-F(E)) | ELISA | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-886LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-886LC) | ELISA | Human IgG |
| MRO-887LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-887LC) | ELISA | Human IgG |
| MRO-888LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-888LC) | ELISA | Human antibody |
| MRO-889LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-889LC) | Neut | Human antibody |
| MRO-890LC | Human Anti-MERS-CoV S Recombinant Antibody (MRO-890LC) | Neut | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2251CQ | Recombinant Mouse Anti-MERS-CoV S Antibody (4) | ELISA, WB, IHC-P, IF/ICC, IP | Mouse antibody |
| HPAB-M0145-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-1) | ELISA, Neut | Humanized IgG |
| HPAB-M0146-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-2) | ELISA, Neut | Humanized IgG |
| HPAB-M0147-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-3) | ELISA, Neut | Humanized IgG |
| HPAB-M0148-YC | Recombinant Humanized Anti-MERS-Cov S Antibody (11F11-4) | ELISA, Neut | Humanized IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-274 | Recombinant Human Anti-MERS-CoV S Antibody scFv Fragment (MCA1) | ELISA, Neut | Human scFv |
| HPAB-M0145-YC-S(P) | Recombinant Humanized Anti-MERS-Cov S Antibody scFv Fragment (11F11-1) | ELISA, Neut | Humanized scFv |
| HPAB-M0146-YC-S(P) | Recombinant Humanized Anti-MERS-Cov S Antibody scFv Fragment (11F11-2) | ELISA, Neut | Humanized scFv |
| HPAB-0310-YJ-S(P) | Human Anti-MERS-CoV S Recombinant Antibody; scFv Fragment (HPAB-0310-YJ-S(P)) | ELISA, Neut, FuncS | Human scFv |
| PABJ-0206-S(P) | Human Anti-MERS-CoV S Recombinant Antibody (clone LCA60); scFv Fragment | Neut | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0145-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-1) | ELISA, Neut | Humanized Fab |
| HPAB-M0146-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-2) | ELISA, Neut | Humanized Fab |
| HPAB-M0147-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-3) | ELISA, Neut | Humanized Fab |
| HPAB-M0148-YC-F(E) | Recombinant Humanized Anti-MERS-Cov S Antibody Fab Fragment (11F11-4) | ELISA, Neut | Humanized Fab |
| PABJ-0206-F(E) | Human Anti-MERS-CoV S Recombinant Antibody (clone LCA60); Fab Fragment | Neut | Human Fab |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-470CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-12) | ELISA, Neut | Camelid VHH |
| NAB-471CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-34) | ELISA, Neut | Camelid VHH |
| NAB-472CQ | Camelid Anti-MERS-CoV S Recombinant Single Domain Antibody (clone VHH-40) | ELISA, Neut | Camelid VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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