Mouse Anti-MME Recombinant Antibody (VS3-CJ498) (CAT#: VS3-CJ498)
This product is a mouse antibody that recognizes human MME (CD10) (Center).
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Duodenum
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_8_2_selected.jpg
Figure 2 High expression in small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_4_2.jpg
Figure 3 Liver
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
(Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
(Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52583/156651_A_7_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (ASC TERT1, BJ hTERT+, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196549-MME
Specifications
- Immunogen
- KLH-conjugated synthetic peptide between 472-505 amino acids from the Central region of human MME
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human MME (CD10) (Center)
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:4000).
Target
- Alternative Names
- NEP; SFE; CD10; CALLA; CMT2T; SCA43
- Gene ID
- 4311
- UniProt ID
- P08473
- Sequence Similarities
- Belongs to the peptidase M13 family.
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Myristoylation is a determinant of membrane targeting.
Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.
- Protein Refseq
- NP_000893.2; NP_009218.2; NP_009219.2
- Function
- Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:6349683, PubMed:6208535, PubMed:15283675, PubMed:8168535).
Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:6349683, PubMed:17101991).
Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535).
Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:6349683, PubMed:15283675).
Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:2531377, PubMed:2972276, PubMed:16254193).
Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "MME"
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L033R | anti-MME immunotoxin SN5d (Fab)-RTA | Cytotoxicity assay, Functional assay | |
| AGTO-L034R | anti-MME immunotoxin SN5d (IgG)-RTA | Cytotoxicity assay, Functional assay |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2246 | Hi-Affi™ Recombinant Rabbit Anti-MME Monoclonal Antibody (DS2246AB) | ICC/IF, WB | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0266-CN | Recombinant Rabbit Anti-MME Monoclonal Antibody (CBACN-103) | WB, FC, IHC, IF | Rabbit IgG |
| HPAB-0244-FY | Recombinant Human Anti-MME Antibody | F | Human IgG1 |
| HPAB-0311-YJ | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5) | IHC, ELISA, WB | Mouse IgG2a |
| VS4-CJ37 | Recombinant Mouse Anti-MME Antibody (VS4-CJ37) | ELISA, IHC | Mouse IgG |
| VS4-CJ38 | Recombinant Mouse Anti-MME Antibody (VS4-CJ38) | ELISA, IF, FC | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-S(P) | Recombinant Human Anti-MME Antibody scFv Fragment | F | Human scFv |
| HPAB-0311-YJ-S(P) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); scFv Fragment | IHC, ELISA, WB | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0244-FY-F(E) | Recombinant Human Anti-MME Antibody Fab Fragment | F | Human Fab |
| HPAB-0311-YJ-F(E) | Mouse Anti-MME Recombinant Antibody (clone 60656-7H5); Fab Fragment | IHC, ELISA, WB | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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