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Afuco™ Anti-NOTCH2 ADCC Recombinant Antibody (Tarextumab), ADCC Enhanced (CAT#: AFC-TAB-H67)

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human NOTCH2. Tarextumab (anti-Notch2/3, OMP-59R5) is a novel anti-cancer stem cell antibody identified by screening against the Notch3 receptor that binds to and prevents signaling through both the Notch2 and Notch3 receptors. Tarextumab has been shown in preclinical models to have broad-spectrum anti-tumor activity via inhibition of cancer stem cell growth, and promoting cell differentiation, as well as disrupting tumor angiogenesis by inhibiting vascular pericytes.


See more Engineered Antibody products for NOTCH2
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Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm & plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/714_F8_1_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_B_7_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_8_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Elongated or late spermatids Staining: Low Intensity: Moderate Quantity: <25% Sertoli cells Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48743/120061_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134250-NOTCH2

Specifications

  • Host Species
  • Human
  • Derivation
  • human
  • Type
  • ADCC enhanced antibody
  • Specificity
  • NOTCH2 (notch 2) [Homo sapiens];
  • Species Reactivity
  • Human
  • Clone
  • Tarextumab
  • Applications
  • IF, IP, Neut, FuncS, ELISA, FC
  • Conjugate
  • Unconjugated
  • Generic Name
  • Tarextumab
  • Related Disease
  • Pancreatic cancers

Product Property

  • Purity
  • >95% by SDS-PAGE
  • Storage
  • Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Tarextumab; 1359940-55-8; OMP-59R5; 59M07; 13M57; anti-Notch2/3; OMP-59R5; NOTCH2; notch 2; Notch (Drosophila) homolog 2, Notch homolog 2 (Drosophila); neurogenic locus notch homolog protein 2; Notch homolog 2; hN2; AGS2; HJCYS;

Related Resources

  • Biosimilar Overview
  • Related Diseases
Please refer to Tarextumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Tarextumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "tarextumab"

Anti-Human NOTCH2 Recombinant Antibody (Tarextumab)
Recombinant human antibody to Human NOTCH2. Tarextumab (anti-Notch2/3, OMP-59R5) is a novel anti-cancer stem cell antibody identified by screening against the Notch3 receptor that binds to and prevents signaling through both the Notch2 and Notch3 receptors. Tarextumab has been shown in preclinical models to have broad-spectrum anti-tumor activity via inhibition of cancer stem cell growth, and promoting cell differentiation, as well as disrupting tumor angiogenesis by inhibiting vascular pericytes.

See other products for "NOTCH2"

Human Antibody

CAT Product Name Application Type
TAB-H67 Anti-Human NOTCH2 Recombinant Antibody (Tarextumab) FuncS, Block, ELISA IgG2 - kappa
TAB-552MZ Human Anti-NOTCH2 Recombinant Antibody (TAB-552MZ) ELISA Human IgG
TAB-552MZ-S(P) Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (TAB-552MZ-S(P)) ELISA Human scFv
TAB-552MZ-F(E) Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (TAB-552MZ-F(E)) ELISA Human Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-0038-CN Human Anti-NOTCH2 Recombinant Antibody (HPAB-0038-CN) FC, ELISA Human IgG2, κ
HPAB-0039-CN Human Anti-NOTCH2 Recombinant Antibody (HPAB-0039-CN) FC, ELISA Human IgG2, κ
HPAB-0595-WJ Human Anti-NOTCH2 Recombinant Antibody (clone D) ELISA, WB Human IgG
HPAB-0596-WJ Human Anti-NOTCH2 Recombinant Antibody (clone D-1) ELISA, WB Human IgG
HPAB-0597-WJ Human Anti-NOTCH2 Recombinant Antibody (clone D-2) ELISA, WB Human IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0038-CN-S(P) Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (HPAB-0038-CN-S(P)) FC, ELISA Human scFv
HPAB-0039-CN-S(P) Human Anti-NOTCH2 Recombinant Antibody; scFv Fragment (HPAB-0039-CN-S(P)) FC, ELISA Human scFv
HPAB-0595-WJ-S(P) Human Anti-NOTCH2 Recombinant Antibody (clone D); scFv Fragment ELISA, WB Human scFv
HPAB-0596-WJ-S(P) Human Anti-NOTCH2 Recombinant Antibody (clone D-1); scFv Fragment ELISA, WB Human scFv
HPAB-0597-WJ-S(P) Human Anti-NOTCH2 Recombinant Antibody (clone D-2); scFv Fragment ELISA, WB Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0038-CN-F(E) Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (HPAB-0038-CN-F(E)) FC, ELISA Human Fab
HPAB-0039-CN-F(E) Human Anti-NOTCH2 Recombinant Antibody; Fab Fragment (HPAB-0039-CN-F(E)) FC, ELISA Human Fab
HPAB-0595-WJ-F(E) Human Anti-NOTCH2 Recombinant Antibody (clone D); Fab Fragment ELISA, WB Human Fab
HPAB-0596-WJ-F(E) Human Anti-NOTCH2 Recombinant Antibody (clone D-1); Fab Fragment ELISA, WB Human Fab
HPAB-0597-WJ-F(E) Human Anti-NOTCH2 Recombinant Antibody (clone D-2); Fab Fragment ELISA, WB Human Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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