Rabbit Anti-NRG3 Recombinant Antibody (clone R02-9E5) (CAT#: VS3-FY1802)
This R02-9E5 recombinant monoclonal antibody exhibits specific binding to human NRG3. It cross-reacts with rat. The NRG3 antibody has been teted positive by western blot analysis of NRG3 in K562, rat brain lysates.
Specific Inquiry
WB
Figure 1 Anti-NRG3 Antibody (VS3-FY1802) in WB.
The NRG3 expression in K562, rat Brain lysates were detected using the anti-NRG3 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human NRG3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat NRG3
- Species Reactivity
- Human, Rat
- Clone
- R02-9E5
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 78 kDa, while the observed molecular weight stands at 55 kDa.
- Related Disease
- Hirschsprung Disease 1 and Schizoaffective Disorder
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Neuregulin 3; Pro-NRG3; Pro-Neuregulin-3, Membrane-Bound Isoform; Neuregulin-3-Like Polypeptide; Neuregulin 3 Variant 10; Neuregulin 3 Variant 11; Neuregulin 3 Variant 12; Neuregulin 3 Variant 13; Neuregulin 3 Variant 14; Neuregulin 3 Variant 1
- Gene ID
- 10718
- UniProt ID
- P56975
- Sequence Similarities
- Belongs to the neuregulin family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. (P56975-NRG3_HUMAN)
Extensive glycosylation precedes the proteolytic cleavage ().
Isoform 3 is glycosylated.
(P56975-NRG3_HUMAN)
Glycosylation at Thr276, Thr277, Thr278, Ser280, and Thr281 (NX_P56975 [NX_P56975-1])
Modification sites at PhosphoSitePlus (P56975)
Glycosylation from GlyGen (P56975) 6 sites, 1 O-linked glycan (6 sites)
- Protein Refseq
- XP_011537474.1; XP_011537475.1; XP_011537477.1; XP_011537480.1; XP_016871062.1
- Function
- Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Recommended Products
Isotype Control
Secondary Antibody
Related Resources
ErbB Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "NRG3"
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2500 | Hi-Affi™ Recombinant Rabbit Anti-NRG3 Monoclonal Antibody (DS2500AB) | WB, FC | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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