Human Anti-P. falciparum Recombinant Antibody (clone MGD21) (CAT#: FAMAB-0003WJ)
This product is a human antibody targeting P. falciparum antigens. This antibody can be tested in several assays including ELISA, WB, and IP. This antibody may be suitable candidate for the development of a malaria vaccine.
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FC
Figure 1 Reactivity and functional assays of MGC and MGD antibodies.
MGD21 staining of 3D7 IE that were enriched or depleted of MGD21 reactivity (n = 3 independent experiments).
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
WB
Figure 2 Reactivity and functional assays of MGC and MGD antibodies.
Western blot showing MGD21 binding to IP prepared from 9605-MGD21- and 9605-MGD21+ IE (representative of n = 2 independent experiments).
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
FC
Figure 3 Reactivity and functional assays of MGC and MGD antibodies.
Binding of MGD21 to CHO cells transfected with RIFINs (PF3D7_1400600 and PF3D7_0100200), a RIFIN chimera containing the constant region of PF3D7_0100200 and the variable region of PF3D7_1400600 (PF3D7_0100200c_1400600v), or the inverse chimera (PF3D7_1400600c_0100200v) (n = 1).
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
IF
Figure 4 Reactivity and functional assays of MGD antibodies.
Agglutinates of 3D7- MGD21+ IE formed by MGD21.
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
ADCC
Figure 5 Reactivity and functional assays of MGC and MGD antibodies.
Opsonic phagocytosis of 11019-MGD21+ IE by monocytes (n = 2). The IE were stained with DAPI, which was quantified in monocytes as a measure of phagocytosis.
Tan, J., Pieper, K., Piccoli, L., Abdi, A., Foglierini, M., Geiger, R., ... & Bejon, P. (2016). A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature, 529(7584), 105-109.
Specifications
- Immunogen
- Plasmodium falciparum antigens
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- P. falciparum antigens
- Species Reactivity
- P. falciparum
- Clone
- MGD21
- Applications
- FC, WB, IF, ADCC
- Related Disease
- P. falciparum infection
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The P. falciparum antibody has been reported in applications of Flow Cytometry, Western Blot, Immunofluorescence, Antibody-dependent Cell-mediated Cytotoxicity.
Target
- Alternative Names
- P. falciparum; Plasmodium; Plasmodiidae; Plasmodium falciparum
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-738 | Recombinant Anti-P. falciparum Antibody | WB, FC, FuncS | IgG |
| MHH-738 | Recombinant Human Anti-P. falciparum Antibody | WB, IF, FuncS | IgG |
| PABC-371 | Recombinant Human Anti-P. falciparum Antibody (MGD21) | FuncS, ELISA, IP, WB | Human IgG |
| FAMAB-0004WJ | Human Anti-P. falciparum Recombinant Antibody (clone MGD34) | ELISA, WB, IP | Human IgG1 |
| FAMAB-0077WJ | Human Anti-P. falciparum Recombinant Antibody (clone MGC34) | ELISA, WB, IP | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-738-F(E) | Recombinant Anti-P. falciparum Antibody Fab Fragment | Neut, IF, FuncS | Fab |
| MHH-738-F(E) | Recombinant Human Anti-P. falciparum Antibody Fab Fragment | ELISA, IF, FuncS | Fab |
| PFBC-371 | Recombinant Human Anti-P. falciparum Antibody Fab Fragment (MGD21) | ELISA, IP, WB | Human Fab |
| FAMAB-0003WJ-F(E) | Human Anti-P. falciparum Recombinant Antibody (clone MGD21); Fab Fragment | ELISA, WB, IP | Human Fab |
| FAMAB-0077WJ-F(E) | Human Anti-P. falciparum Recombinant Antibody (clone MGC34); Fab Fragment | ELISA, WB, IP | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-012CT | Recombinant Mouse Anti-Plasmodium falciparum Antibody | Dot, ELISA, WB |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-371 | Recombinant Human Anti-P. falciparum Antibody scFv Fragment (MGD21) | ELISA, IP, WB | Human scFv |
| FAMAB-0003WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGD21); scFv Fragment | ELISA, WB, IP | Human scFv |
| FAMAB-0004WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGD34); scFv Fragment | ELISA, WB, IP | Human scFv |
| FAMAB-0005WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGD39); scFv Fragment | ELISA, WB, IP | Human scFv |
| FAMAB-0077WJ-S(P) | Human Anti-P. falciparum Recombinant Antibody (clone MGC34); scFv Fragment | ELISA, WB, IP | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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