Human Anti-PDGFRB Recombinant Antibody (clone PFH2); Fab Fragment (CAT#: HPAB-N0227-YC-F(E))
Provided herein are antibodies that bind to PDGFRβ. Additional studies were conducted which revealed that antibodies PFH2 inhibit phosphorylation of PDGFR and downstream signaling molecule map-kinase (MAPK) in response to stimulation by PDGFbb.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line ASC TERT1
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28499/1774_C4_13_cr5950fa3646972_selected.jpg
(Immunofluorescent staining of human cell line ASC TERT1 shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/28499/1774_C4_13_cr5950fa3646972_selected.jpg
Figure 2 Testis
(Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Peritubular cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_4_6.jpg
(Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Peritubular cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_4_6.jpg
Figure 3 Placenta
(Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_2_7.jpg
(Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_2_7.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_B_9_5.jpg
Figure 5 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_9_4.jpg
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_8_5.jpg
Figure 7 RNA cell line category: Group enriched (ASC diff, ASC TERT1)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113721-PDGFRB
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113721-PDGFRB
Specifications
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human Fab
- Specificity
- Human PDGFRB
- Species Reactivity
- Human, Mouse, Rat
- Clone
- PFH2
- Applications
- Block
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Platelet Derived Growth Factor Receptor Beta; Platelet-Derived Growth Factor Receptor, Beta Polypeptide; Beta-Type Platelet-Derived Growth Factor Receptor; Platelet-Derived Growth Factor Receptor 1; CD140 Antigen-Like Family Member B; PDGF-R-Beta; EC 2.7.10.1; PDGFR-Beta; PDGFR-1; PDGFR1; PDGFR; Platelet-Derived Growth Factor Receptor Beta
- Gene ID
- 5159
- UniProt ID
- P09619
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone PFH2"
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0988CL-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (TAB-0988CL-S(P)) | ELISA | Human scFv |
| TAB-0988CL-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (TAB-0988CL-F(E)) | ELISA | Human Fab |
| TAB-0989CL-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (TAB-0989CL-F(E)) | ELISA | Human Fab |
| TAB-0990CL-F(E) | Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (TAB-0990CL-F(E)) | ELISA | Human Fab |
| TAB-0991CL-F(E) | Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL-F(E)); Fab Fragment | ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2107MZ | Recombinant Mouse Anti-Human PDGFRB Antibody (clone 29B3), PE-Conjugated | FC | Mouse antibody |
| HPAB-S0105-YC | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11) | ELISA, Neut | Mouse IgG |
| HPAB-S0106-YC | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11) | ELISA, Neut | Humanized IgG |
| HPAB-S0107-YC | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22) | ELISA, Neut | Mouse IgG |
| HPAB-S0108-YC | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22) | ELISA, Neut | Humanized IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1850CQ | Recombinant Rat Anti-Pdgfrb Antibody (APB5) | FC, FuncS, Neut | IgG2a, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2638 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB) | WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0281CQ-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment | ELISA, FC, WB, Neut | Human Fab |
| HPAB-S0105-YC-F(E) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); Fab Fragment | ELISA, Neut | Mouse Fab |
| HPAB-S0106-YC-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); Fab Fragment | ELISA, Neut | Humanized Fab |
| HPAB-S0107-YC-F(E) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); Fab Fragment | ELISA, Neut | Mouse Fab |
| HPAB-S0108-YC-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); Fab Fragment | ELISA, Neut | Humanized Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0281CQ-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); scFv Fragment | ELISA, FC, WB, Neut | Human scFv |
| HPAB-1110-CN-S(P) | Mouse Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1110-CN-S(P)) | ELISA | Mouse scFv |
| HPAB-1111-CN-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1111-CN-S(P)) | ELISA | Human scFv |
| HPAB-1112-CN-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1112-CN-S(P)) | ELISA | Human scFv |
| HPAB-1113-CN-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1113-CN-S(P)) | ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-448CQ | Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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