Rabbit Anti-SATB2 Recombinant Antibody (clone R02-1H5) (CAT#: VS3-FY1624)

• Immunogen
• Synthetic peptide of human SATB2

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Rat SATB2

• Species Reactivity
• Human, Rat

• Clone
• R02-1H5

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 83 kDa, while the observed molecular weight stands at 83 kDa.

• Related Disease
• Glass Syndrome and Cleft Palate, Isolated

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• SATB Homeobox 2; Special AT-Rich Sequence-Binding Protein 2; SATB Family Member 2; DNA-Binding Protein SATB2; KIAA1034; GLSS

• Gene ID
• 23314

• UniProt ID
• Q9UPW6

• Sequence Similarities
• Belongs to the CUT homeobox family.

• Cellular Localization
• Nucleus

• Post Translation Modifications
• Sumoylated by PIAS1. Sumoylation promotes nuclear localization, but represses transcription factor activity.

• Protein Refseq
• NP_001165980.1; NP_001165988.1; NP_056080.1

• Function
• Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody