Rabbit Anti-SDC1 Recombinant Antibody (clone R07-9H1) (CAT#: VS3-XY3496)
It is a recombinant rabbit antibody targeting the SDC1 (Syndecan 1), which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. The antibody reacts with human, mouse and rat SDC1. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western blot, Immunohistochemistry-Paraffin and Immunofluorescence is 1/500-1/1000, 1/50-1/100 and 1/50-1/200, respectively.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to focal adhesion sites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to focal adhesion sites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/if_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_B_8_5.jpg
Figure 3 Colon
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_3.jpg
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_3.jpg
Figure 4 Testis
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_4_6.jpg
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_4_6.jpg
Figure 5 Placenta
(Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_1_7.jpg
(Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_1_7.jpg
Figure 6 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_8.jpg
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115884-SDC1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115884-SDC1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SDC1
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R07-9H1
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Monoclonal Gammopathy of Uncertain Significance and Endometritis
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- SDC; CD138; SYND1; syndecan
- Gene ID
- 6382
- UniProt ID
- P18827
- Long Name
- Syndecan 1
- Cellular Localization
- Membrane, Secreted
- Post Translation Modifications
- Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF.
Also by stress and wound healing.
PMA-mediated shedding is inhibited by TIMP3.
- Protein Refseq
- XP_005262677.1
- Function
- Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity).
Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "SDC1"
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-197 | Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (clone Indatuximab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Chimeric (mouse/Human) IgG4, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-495CT | Mouse Anti-SDC1 Recombinant Antibody (TAB-495CT) | FC, WB | Mouse IgG1, κ |
| TAB-495CT-S(P) | Mouse Anti-SDC1 Recombinant Antibody; scFv Fragment (TAB-495CT-S(P)) | FC, WB | Mouse scFv |
| TAB-495CT-F(E) | Mouse Anti-SDC1 Recombinant Antibody; Fab Fragment (TAB-495CT-F(E)) | FC, WB | Mouse Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3189 | Hi-Affi™ Recombinant Rabbit Anti-SDC1 Monoclonal Antibody (DS3189AB) | IHC-P | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0324-CN | Human Anti-SDC1 Recombinant Antibody (HPAB-0324-CN) | ELISA, FC | Humanized IgG3, κ |
| HPAB-0326-CN | Human Anti-SDC1 Recombinant Antibody (HPAB-0326-CN) | ELISA, FC | Humanized IgG4, κ |
| MRO-1463-CN | Recombinant Rabbit Anti-SDC1 Monoclonal Antibody (JM11-21) | WB, IF, IHC | Rabbit IgG |
| FN-069CQ | Recombinant Mouse Anti-SDC1 Antibody (B-A38) | FC, IHC | Mouse IgG1 |
| ZG-0184U | Mouse Anti-Sdc1 Recombinant Antibody (clone 1B4F4) | ELISA | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0324-CN-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-0324-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0326-CN-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-0326-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-2546LY-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-2546LY-S(P)) | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0324-CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0324-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-0326-CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0326-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-2546LY-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-2546LY-F(E)) | ELISA | Humanized Fab |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-086CN | Human Anti-SDC1 Recombinant Antibody (NS-086CN) | ELISA | Humanized IgG |
| NS-087CN | Human Anti-SDC1 Recombinant Antibody (NS-087CN) | ELISA | Humanized IgG |
| NS-086CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-086CN-F(E)) | ELISA | Humanized Fab |
| NS-087CN-F(E) | Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-087CN-F(E)) | ELISA | Humanized Fab |
| NS-086CN-S(P) | Human Anti-SDC1 Recombinant Antibody; scFv Fragment (NS-086CN-S(P)) | ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-197 | Afuco™ Anti-SDC1 ADCC Recombinant Antibody (Indatuximab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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