Rabbit Anti-SLC4A1 Recombinant Antibody (clone R07-8A4) (CAT#: VS3-FY1662)

• Immunogen
• Synthetic peptides of human Band 3

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human and Mouse SLC4A1

• Species Reactivity
• Human, Mouse

• Clone
• R07-8A4

• Applications
• Western Blot

• MW
• The calculated weight of the target protein is approximately 102 kDa, while the observed molecular weight stands at 102 kDa.

• Related Disease
• Destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• Solute Carrier Family 4 Member 1 (Diego Blood Group); Solute Carrier Family 4, Anion Exchanger, Member 1 (Erythrocyte Membrane Protein Band 3, Diego Blood Group); Solute Carrier Family 4 (Anion Exchanger), Member 1 (Diego Blood Group); Erythrocyte Membrane Protein Band 3; Anion Exchange Protein 1; Waldner Blood Group; Froese Blood Group; Wright Blood Group; Swann Blood Group; Diego Blood Group; EPB3; AE1; DI; Solute Carrier Family 4 (Anion Exchanger), Member 1; Solute Carrier Family 4, Anion Exchanger, Number 1; Erythroid Anion Exchange Protein; Solute Carrier Family 4 Member 1; Band 3 Anion Transport Protein

• Gene ID
• 6521

• UniProt ID
• P02730

• Sequence Similarities
• Belongs to the anion exchanger (TC 2.A.31) family.

• Cellular Localization
• Cell membrane, Membrane

• Post Translation Modifications
• Phosphorylated on Tyr-8 and Tyr-21 most likely by SYK. PP1-resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation., Phosphorylated on Tyr-359 and Tyr-904 most likely by LYN. PP1-inhibited phosphorylation that follows Tyr-8 and Tyr-21 phosphorylation., N-glycosylated.

• Protein Refseq
• NP_000333.1

• Function
• Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.
  (Microbial infection) Acts as a receptor for P.falciparum (isolate 3D7) MSP9 and thus, facilitates merozoite invasion of erythrocytes.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody