Rabbit Anti-TARDBP Recombinant Antibody (clone R06-3G4) (CAT#: VS3-FY1897)
This R06-3G4 recombinant monoclonal antibody is designed to target human TARDBP. It cross-reacts with mouse, rat. It is suitable for use in a variety of assays, including WB, IHC-F, IHC-P, ICC/IF, IP. We verify the QC result of the antibody through western blot (dilution 1/500-1/1000), immunohistochemistry (dilution 1/50-1/100), immunofluorescence (dilution 1/50-1/200), immunoprecipitation (dilution 1/20). The specificity of the TDP 43 antibody was confirmed by western blot analysis of TDP43 in K562, C6, 3T3, Hela lysates and immunocytochemistry analysis of paraffin-embedded human brain.
Specific Inquiry
WB
Figure 1 Anti-TARDBP Antibody (VS3-FY1897) in WB.
The TDP43 expression in K562, C6, 3T3, Hela lysates were detected using the anti-TDP43 by western blot assay.
ICC
Figure 2 Anti-TARDBP Antibody (VS3-FY1897) in ICC.
Immunocytochemistry staining of paraffin-embedded Human brain using the anti-TDP 43 antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Specifications
- Immunogen
- Synthetic peptide of human TDP43
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TARDBP
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-3G4
- Applications
- Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 45 kDa, while the observed molecular weight stands at 45 kDa.
- Related Disease
- Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia and Motor Neuron Disease
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunofluorescence: 1/50-1/200
Immunoprecipitation: 1/20
Target
- Alternative Names
- TAR DNA Binding Protein; TDP-43; TAR DNA-Binding Protein 43; TAR DNA-Binding Protein-43; ALS10; TDP43
- Gene ID
- 23435
- UniProt ID
- Q13148
- Cellular Localization
- Cytoplasm, Mitochondrion, Nucleus
- Post Translation Modifications
- Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
Phosphorylated upon cellular stress.
(Q13148-TADBP_HUMAN)
Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. (Q13148-TADBP_HUMAN)
Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. (Q13148-TADBP_HUMAN)
- Protein Refseq
- NP_031401.1
- Function
- Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts.
Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TARDBP"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2370-VHH | Recombinant Anti-Human TARDBP VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2045z | Mouse Anti-TARDBP Recombinant Antibody (clone 27H10) | WB, ICC, IF, IHC | Mouse IgG1 |
| MOB-1542MZ | Recombinant Mouse Anti-Human TARDBP Antibody | ICC/IF, IHC-P, WB | Mouse antibody |
| HPAB-0148-YC | Mouse Anti-TARDBP Recombinant Antibody (HPAB-0148-YC) | ELISA, FC, RIA | Mouse IgG2a, κ |
| HPAB-0149-YC | Mouse Anti-TARDBP Recombinant Antibody (HPAB-0149-YC) | ELISA, Inhib | Mouse IgG |
| VS3-FY1426 | Recombinant Rabbit Anti-TARDBP Antibody (clone R02-2A8) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0283CL | Mouse Anti-TARDBP Recombinant Antibody (TAB-0283CL) | WB, IF | Mouse IgG |
| TAB-0283CL-S(P) | Mouse Anti-TARDBP Recombinant Antibody; scFv Fragment (TAB-0283CL-S(P)) | WB, ELISA | Mouse scFv |
| TAB-0283CL-F(E) | Mouse Anti-TARDBP Recombinant Antibody; Fab Fragment (TAB-0283CL-F(E)) | WB, ELISA | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-569CT | Human Anti-TARDBP Recombinant Antibody (TAB-569CT) | ELISA, FC, WB | Human IgG |
| TAB-570CT | Human Anti-TARDBP Recombinant Antibody (TAB-570CT) | ELISA, FC, WB | Human IgG |
| TAB-571CT | Human Anti-TARDBP Recombinant Antibody (TAB-571CT) | ELISA, FC, WB | Human IgG |
| TAB-572CT | Human Anti-TARDBP Recombinant Antibody (TAB-572CT) | ELISA, FC, WB | Human IgG |
| TAB-573CT | Human Anti-TARDBP Recombinant Antibody (TAB-573CT) | ELISA, FC, WB | Human IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3504 | Hi-Affi™ Recombinant Rabbit Anti-TARDBP Monoclonal Antibody (DS3504AB) | WB, IHC, ICC, IP | IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0148-YC-S(P) | Mouse Anti-TARDBP Recombinant Antibody; scFv Fragment (HPAB-0148-YC-S(P)) | ELISA, FC, RIA | Mouse scFv |
| HPAB-0149-YC-S(P) | Mouse Anti-TARDBP Recombinant Antibody; scFv Fragment (HPAB-0149-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0150-YC-S(P) | Mouse Anti-TARDBP Recombinant Antibody; scFv Fragment (HPAB-0150-YC-S(P)) | ELISA, Block | Mouse scFv |
| NS-091CN-S(P) | Rabbit Anti-TARDBP Recombinant Antibody; scFv Fragment (NS-091CN-S(P)) | ELISA, IHC, IP, ICC, IF | Rabbit scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0148-YC-F(E) | Mouse Anti-TARDBP Recombinant Antibody; Fab Fragment (HPAB-0148-YC-F(E)) | ELISA, FC, RIA | Mouse Fab |
| HPAB-0149-YC-F(E) | Mouse Anti-TARDBP Recombinant Antibody; Fab Fragment (HPAB-0149-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-0150-YC-F(E) | Mouse Anti-TARDBP Recombinant Antibody; Fab Fragment (HPAB-0150-YC-F(E)) | ELISA, Block | Mouse Fab |
| NS-091CN-F(E) | Rabbit Anti-TARDBP Recombinant Antibody; Fab Fragment (NS-091CN-F(E)) | ELISA, IHC, IP, ICC, IF | Rabbit Fab |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-091CN | Rabbit Anti-TARDBP Recombinant Antibody (NS-091CN) | ELISA, IHC, IP, ICC, IF | Rabbit IgG2a, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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