This product is a recombinant mouse antibody that recognizes TIGIT. The antibody was purified by affinity chromatography. It can be used in Block, ELISA, FC.
Figure 1 Anti-TIGIT Abs modulate T cell responses in vivo.
Wild type B6 mice were immunized s.c. with 100 µg MOG35-55 peptide in CFA and received 100 µg anti-TIGIT (or isotype control: Armenian hamster IgG for clone 4D4 or mouse IgG1 for 1G9 and 1B4) antibody i.p on days 0, 2, and 4. On day 10 spleens and lymph nodes were harvested and cells were re-stimulated with MOG35-55 peptide. (dLN: draining lymph node).
Dixon, K. O., Schorer, M., Nevin, J., Etminan, Y., Amoozgar, Z., Kondo, T., ... & Joller, N. (2018). Functional anti-TIGIT antibodies regulate development of autoimmunity and antitumor immunity. The Journal of Immunology, 200(8), 3000-3007.
Figure 2 Functional anti-TIGIT Abs modulate disease severity in EAE.
Wild type B6 mice were immunized s.c. with 100 µg (A, B; D, E) or 10-15µg (C; F) MOG35-55 peptide in CFA, followed by injection of 100 ng pertussis toxin i.v. on day 0 and day 2. Mice also received 100 µg anti-TIGIT (or isotype control: Armenian hamster IgG for clone 4D4 or mouse IgG1 for 1G9 and 1B4) antibody i.p on days 0, 2, 4, 10, and 17 and were monitored daily for EAE.
Dixon, K. O., Schorer, M., Nevin, J., Etminan, Y., Amoozgar, Z., Kondo, T., ... & Joller, N. (2018). Functional anti-TIGIT antibodies regulate development of autoimmunity and antitumor immunity. The Journal of Immunology, 200(8), 3000-3007.
Figure 3 Blocking anti-TIGIT Abs have synergistic effects with blockade of other coinhibitory receptors in cancer.
Wild-type C57BL/6 mice were implanted with MC38 colon carcinoma. Mice with established tumors were treated with anti-PD-1, anti-TIGIT, anti-PD-1 + anti-TIGIT (COMBO), or isotype controls (ISO) and monitored for tumor growth. (A) Mean (left) and individual (right) tumor growth curves are shown (n = 5 per group). Similar results were obtained in an independent experiment. (
Dixon, K. O., Schorer, M., Nevin, J., Etminan, Y., Amoozgar, Z., Kondo, T., ... & Joller, N. (2018). Functional anti-TIGIT antibodies regulate development of autoimmunity and antitumor immunity. The Journal of Immunology, 200(8), 3000-3007.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0279CL | Hamster Anti-TIGIT Recombinant Antibody (TAB-0279CL) | FuncS | Hamster IgG |
TAB-0280CL | Hamster Anti-TIGIT Recombinant Antibody (TAB-0280CL) | Inhib, WB, FC | Hamster IgG |
TAB-659CT-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-659CT-F(E)) | WB, ELISA, FC, Inhib | Mouse Fab |
TAB-660CT-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-660CT-F(E)) | WB, ELISA, FC, Inhib | Mouse Fab |
TAB-661CT-F(E) | Rat Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-661CT-F(E)) | WB, ELISA, FC, Inhib | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-662CT | Humanized Anti-TIGIT Recombinant Antibody (TAB-662CT) | WB, ELISA, FC, Inhib | Humanized IgG4 |
TAB-663CT | Humanized Anti-TIGIT Recombinant Antibody (TAB-663CT) | WB, ELISA, FC, Inhib | Humanized IgG4 |
TAB-662CT-S(P) | Humanized Anti-TIGIT Recombinant Antibody; scFv Fragment (TAB-662CT-S(P)) | WB, ELISA, FC, Inhib | Humanized scFv |
TAB-662CT-F(E) | Humanized Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-662CT-F(E)) | WB, ELISA, FC, Inhib | Humanized Fab |
TAB-663CT-F(E) | Humanized Anti-TIGIT Recombinant Antibody; Fab Fragment (TAB-663CT-F(E)) | WB, ELISA, FC, Inhib | Humanized Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-2025CQ | Mouse Anti-TIGIT Recombinant Antibody (clone 1G9) | FC, FuncS | Mouse IgG1, κ |
NEUT-2026CQ | Mouse Anti-TIGIT Recombinant Antibody (clone CBL382) | Block | Mouse IgG1 |
NEUT-2027CQ | Mouse Anti-TIGIT Recombinant Antibody (clone CBL383) | Block, CyTOF, FC | Mouse IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0019CQ | Mouse Anti-TIGIT Recombinant Antibody (HPAB-0019CQ) | ELISA, FC, Inhib | Mouse IgG2a, κ |
HPAB-0020CQ | Mouse Anti-TIGIT Recombinant Antibody (HPAB-0020CQ) | ELISA, FC, Inhib | Mouse IgG2a, κ |
HPAB-0021CQ | Mouse Anti-TIGIT Recombinant Antibody (HPAB-0021CQ) | ELISA, FC, FuncS | Mouse IgG2a, κ |
HPAB-0022CQ | Human Anti-TIGIT Recombinant Antibody (HPAB-0022CQ) | ELISA, FC, Block, FuncS | Humanized IgG1, κ |
HPAB-0023CQ | Human Anti-TIGIT Recombinant Antibody (HPAB-0023CQ) | ELISA, FC, Block, FuncS | Humanized IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-603-FY-S(P) | Mouse Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-603-FY-S(P)) | FC, ELISA | Mouse scFv |
HPAB-2630LY-S(P) | Mouse Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-2630LY-S(P)) | ELISA | Mouse scfv |
HPAB-0669YY-S(P) | Human Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0669YY-S(P)) | WB, FC, ELISA | Human scFv |
HPAB-0906-YJ-S(P) | Human Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0906-YJ-S(P)) | ELISA, Block | Human scFv |
HPAB-0907-YJ-S(P) | Human Anti-TIGIT Recombinant Antibody; scFv Fragment (HPAB-0907-YJ-S(P)) | ELISA, Block | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-603-FY-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-603-FY-F(E)) | FC, ELISA | Mouse Fab |
HPAB-2630LY-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-2630LY-F(E)) | ELISA | Mouse Fab |
HPAB-2631LY-F(E) | Human Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-2631LY-F(E)) | ELISA | Human Fab |
HPAB-2632LY-F(E) | Mouse Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-2632LY-F(E)) | ELISA | Mouse Fab |
HPAB-2633LY-F(E) | Human Anti-TIGIT Recombinant Antibody; Fab Fragment (HPAB-2633LY-F(E)) | ELISA | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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