Human Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2) (CAT#: HPAB-0333-YJ)
This product is a recombinant Chimeric (Human/Mouse) antibody that recognizes human TNFRSF25. It displays a decreased agonistic activity or no agonistic activity for DR3.
Specific Inquiry
FuncS
Figure 1 indicate comparison of isotype effects on anti-DR3 antibody agonist activities.
The effects of indicated 142A2 IgG1, IgG2, and IgG4v versions on PBMCs NF-kB activation were determined. The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates added antibodies. TL1A was added at 40 nM concentration and each antibody was added at 6.67 nM concentration.
FuncS
Figure 2 indicate comparison of isotype effects on anti-DR3 antibody antagonist activities.
The effects of indicated 142A2 IgG1, IgG2, and IgG4v versions on PBMCs NF-kB activation were determined. The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates added antibodies. TL1A was added at 40 nM concentration and each antibody was added at 6.67 nM concentration.
FuncS
Figure 3 indicate an agonism on p65 phosphorylation level of anti-DR3 antibody IgG2, IgG4 variant, IgG4244 variant and IgG2422 variant.
The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates antibody concentration (nM).
FuncS
Figure 4 indicate an antagonism on p65 phosphorylation level of anti-DR3 antibody IgG2, IgG4 variant, IgG4244 variant and IgG2422 variant.
The longitudinal axis indicates p65 phosphorylation-positive cells (%) in PBMCs and the horizontal axis indicates antibody concentration (μgmL). 55% and 1.8% of cells were phosphorylated-p65 positive following TL1A treatment alone or medium alone.
Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric (mouse/human) IgG2, κ
- Specificity
- Human TNFRSF25
- Species Reactivity
- Human
- Clone
- Ch142A2
- Applications
- FC, Antagonism, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytometry, Antagonism, Functional Assay.
Target
- Alternative Names
- DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12; death receptor 3; tumor necrosis factor receptor superfamily member 25; Guanine nucleotide exchange factor 720; PH domain-containing family G member 5; Pleckstrin homology domain-containing family G member 5; apoptosis inducing receptor; apoptosis-inducing receptor AIR; apoptosis-mediating receptor DR3; apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; death receptor beta; lymphocyte-associated receptor of death; protein WSL-1; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
- Gene ID
- 8718
- UniProt ID
- Q93038
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone Ch142A2"
See other products for "TNFRSF25"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-242MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-242MZ) | ELISA | Mouse lgG1 |
| TAB-243MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-243MZ) | ELISA | Mouse lgG1 |
| TAB-244MZ | Mouse Anti-TNFRSF25 Recombinant Antibody (TAB-244MZ) | ELISA | Mouse IgG2a |
| TAB-245MZ | Anti-Human TNFRSF25 Recombinant Antibody (11H08 ) | Agonist, Block, FC, FuncS | |
| TAB-242MZ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (TAB-242MZ-S(P)) | ELISA | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-246MZ | Anti-Human TNFRSF25 Recombinant Antibody (11H08_H1) | Agonist, Block, FC, FuncS | Humanized antibody |
| TAB-246MZ-S(P) | Anti-Human TNFRSF25 Recombinant Antibody scFv Fragment (11H08_H1) | FC | Humanized antibody |
| TAB-246MZ-F(E) | Anti-Human TNFRSF25 Recombinant Antibody Fab Fragment (11H08_H1) | FC | Humanized antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2089MZ | Recombinant Mouse Anti-Human TNFRSF25 Antibody (clone 1H2) | WB | Mouse antibody |
| HPAB-0722YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0722YY) | ELISA | Humanized IgG |
| HPAB-0723YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0723YY) | ELISA | Humanized IgG |
| HPAB-0788YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0788YY) | ELISA, FC, ADCC | Humanized IgG |
| HPAB-0789YY | Human Anti-TNFRSF25 Recombinant Antibody (HPAB-0789YY) | ELISA, FC, ADCC | Humanized IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0333-YJ-S(P) | Mouse Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2); scFv Fragment | FC, Antagonist | Mouse scFv |
| HPAB-0722YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0722YY-S(P)) | ELISA | Human scFv |
| HPAB-0723YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0723YY-S(P)) | ELISA | Human scFv |
| HPAB-0788YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0788YY-S(P)) | ELISA | Human scFv |
| HPAB-0789YY-S(P) | Human Anti-TNFRSF25 Recombinant Antibody; scFv Fragment (HPAB-0789YY-S(P)) | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0333-YJ-F(E) | Human Anti-TNFRSF25 Recombinant Antibody (clone Ch142A2); Fab Fragment | FC, Antagonist | Human Fab |
| HPAB-0722YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0722YY-F(E)) | ELISA | Humanized Fab |
| HPAB-0723YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0723YY-F(E)) | ELISA | Humanized Fab |
| HPAB-0788YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0788YY-F(E)) | ELISA | Humanized Fab |
| HPAB-0789YY-F(E) | Human Anti-TNFRSF25 Recombinant Antibody; Fab Fragment (HPAB-0789YY-F(E)) | ELISA | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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