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  • Human Anti-TNFSF10 Recombinant Antibody (clone DR4-4)

Human Anti-TNFSF10 Recombinant Antibody (clone DR4-4) (CAT#: VS-0423-CJ41)

This Human anti-TNFSF10 antibody (clone DR4-4) is a product that recognizes Human recombinant DR4.


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Specific Inquiry
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  • Conjugation:
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  • Purity:
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  • Gene Expression
  • Datasheet
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  • COA
Subcellular Location and Protein Expression
Figure 1 IHC staining of human kidney
Figure 1 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_7_5.jpg
Figure 5 Testis
Figure 5 Testis
(Cells in seminiferous ducts
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_4_6.jpg
Figure 6 Lymph node
Figure 6 Lymph node
(Germinal center cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (BEWO, CAPAN-2, HaCaT, HMC-1, RPTEC TERT1)
Figure 7 RNA cell line category: Cell line enhanced (BEWO, CAPAN-2, HaCaT, HMC-1, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000121858-TNFSF10/subcellular

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human TNFSF10
  • Species Reactivity
  • Human
  • Clone
  • DR4-4
  • Applications
  • IB, IA, FC
  • Conjugate
  • Unconjugated
  • Related Disease
  • Tumors

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Buffer
  • PBS
  • Storage
  • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Immunoblotting, Immunoassay, Flow Cytometry.

Target

  • Alternative Names
  • TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A
  • Sequence Similarities
  • Belongs to the tumor necrosis factor family.
  • Cellular Localization
  • Cell membrane, Membrane, Secreted
  • Post Translation Modifications
  • Tyrosine phosphorylated by PKDCC/VLK.
  • Function
  • Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
    Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Recommended Products

Isotype Control

Secondary Antibody

Recommended Dilution Buffer

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "TNFSF10"

Recombinant Antibody

CAT Product Name Application Type
MOB-987 Recombinant Anti-human TNFSF10 Antibody ELISA, WB, FC, FuncS IgG
MHH-987 Recombinant Human Anti-human TNFSF10 Antibody ELISA, WB, FC, FuncS IgG
MOB-0837MZ Recombinant Mouse Anti-Human TNFSF10 Antibody (clone C-T34) FC Mouse antibody
HPAB-1451-FY Human Anti-TNFSF10 Recombinant Antibody (HPAB-1451-FY) Activ Humanized IgG
VS3-FY1468 Recombinant Mouse Anti-TNFSF10 Antibody (clone 6D4C6) ELISA, FC Mouse IgG1

Fab Fragment Antibody

CAT Product Name Application Type
MOB-987-F(E) Recombinant Anti-human TNFSF10 Antibody Fab Fragment ELISA, FuncS Fab
MHH-987-F(E) Recombinant Human Anti-human TNFSF10 Antibody Fab Fragment FC, RIA, Biosensors, FuncS Fab
HPAB-1451-FY-S(P) Human Anti-TNFSF10 Recombinant Antibody; scFv Fragment (HPAB-1451-FY-S(P)) Activ Humanized scFv

scFv Fragment Antibody

CAT Product Name Application Type
MOB-987-S(P) Recombinant Anti-human TNFSF10 Antibody scFv Fragment FC, Neut, Funcs scFv
MHH-987-S(P) Recombinant Human Anti-human TNFSF10 Antibody scFv Fragment ELISA, IP, FuncS scFv
HPAB-1451-FY-F(E) Human Anti-TNFSF10 Recombinant Antibody; Fab Fragment (HPAB-1451-FY-F(E)) Activ Humanized Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0598MZ Chicken Anti-TNFSF10 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2170CQ Mouse Anti-TNFSF10 Recombinant Antibody (clone RIK-2) FC, FuncS, Neut Mouse IgG1, κ
NEUT-2171CQ Rat Anti-Tnfsf10 Recombinant Antibody (clone N2B2) FC, FuncS, Neut Rat IgG2a, κ
NEUT-2172CQ Mouse Anti-TNFSF10 Recombinant Antibody (clone CBL186) FC, IHC, Neut, WB Mouse IgG1
NEUT-2173CQ Mouse Anti-TNFSF10 Recombinant Antibody (clone 2B7) ELISA, Neut, WB Mouse IgG1, κ
NEUT-2174CQ Mouse Anti-TNFSF10 Recombinant Antibody (clone 2E5) FuncS, FC, Neut Mouse IgG1

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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