Mouse Anti-TNFSF15 Recombinant Antibody (clone TAN2-2) (CAT#: FAMAB-1420CQ)

Figure 1 DR3 is required for optimal pathology and IL-9 and IL-13 production by T cells in response to an inhaled allergen.

Localization of TL1A expression in the lungs of WT mice treated with papain is demonstrated by immunohistochemistry.

Richard, A. C., Tan, C., Hawley, E. T., Gomez-Rodriguez, J., Goswami, R., Yang, X. P., ... & Gabay, O. (2015). The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells. The Journal of Immunology, 194(8), 3567-3582.

Figure 2 TL1A enhances IL-9 production by T cells differentiated under Th9 and iTreg conditions.

Naïve CD4+ T cells from WT and Tnfrsf25-/- mice were differentiated for 3 days under iTreg conditions with or without TL1A, in the absence or presence of T-depleted antigen presenting cells (APC).

Richard, A. C., Tan, C., Hawley, E. T., Gomez-Rodriguez, J., Goswami, R., Yang, X. P., ... & Gabay, O. (2015). The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells. The Journal of Immunology, 194(8), 3567-3582.

Figure 3 TL1A-induced Th9 differentiation depends on IL-2 and STAT5.

Naïve CD4+ T cells were polarized under Th9 conditions with or without TL1A, with the indicated blocking antibodies or added cytokines.

Richard, A. C., Tan, C., Hawley, E. T., Gomez-Rodriguez, J., Goswami, R., Yang, X. P., ... & Gabay, O. (2015). The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells. The Journal of Immunology, 194(8), 3567-3582.

Figure 4 TL1A enhances ocular inflammation induced by Th9.

Histological sections showing conjunctivitis in recipients of Th9 and TL1A-stimulated Th9 cells are representative of 3 independent experiments.

Richard, A. C., Tan, C., Hawley, E. T., Gomez-Rodriguez, J., Goswami, R., Yang, X. P., ... & Gabay, O. (2015). The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell–Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9–Producing T Cells. The Journal of Immunology, 194(8), 3567-3582.