This product is an antibody that recognizes TTR. The antibody 14G8 can be used for immunoassay techniques such as: WB, FC, ELISA.
Figure 1 Characterization of 14G8 mAb by Western blot analysis.
Native TTR (TTR) and pH4-TTR (F) were separated by non-denaturing SDS-PAGE and Western blotted with 14G8 mAb. pH4-TTR migrated as a 15 kDa monomer and a 32 kDa non-native dimer.
Higaki, J. N., Chakrabartty, A., Galant, N. J., Hadley, K. C., Hammerson, B., Nijjar, T., ... & Tam, S. J. (2016). Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid, 23(2), 86-97.
Figure 2 TTR mAb-dependent phagocytosis.
All four anti-misTTR antibodies increased uptake of aggregated pHrodo-ATTR V30M in a dose-dependent fashion as measured by pHrodo-positive THP-1 cells. In contrast, no uptake was observed in cells treated with an isotype control IgG and no fluorescence was detected in untreated cells (red circle).
Higaki, J. N., Chakrabartty, A., Galant, N. J., Hadley, K. C., Hammerson, B., Nijjar, T., ... & Tam, S. J. (2016). Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid, 23(2), 86-97.
Figure 3 Staining of TTR by the 14G8 mis-TTR mAb.
14G8 did stain intracellular TTR present in normal pancreatic α-cells.
Higaki, J. N., Chakrabartty, A., Galant, N. J., Hadley, K. C., Hammerson, B., Nijjar, T., ... & Tam, S. J. (2016). Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin. Amyloid, 23(2), 86-97.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-2498-sdAb | Recombinant Anti-human TTR VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
HPAB-0483-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (clone 1) | ELISA | Camel VHH |
HPAB-0484-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (clone 5) | ELISA | Camel VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBZ-128 | Mouse Anti-TTR Recombinant Antibody (clone 39-44); scFv Fragment | WB, Block | Mouse scFv |
HPAB-0642LY-S(P) | Mouse Anti-TTR Recombinant Antibody (clone 14G8); scfv Fragment | WB, FC, ELISA | Mouse scfv |
HPAB-0643LY-S(P) | Human Anti-TTR Recombinant Antibody (clone Hu14G8v1); scfv Fragment | WB, FC, ELISA | Humanized scfv |
HPAB-0644LY-S(P) | Human Anti-TTR Recombinant Antibody (clone Hu14G8v2); scfv Fragment | WB, FC, ELISA | Humanized scfv |
HPAB-0645LY-S(P) | Human Anti-TTR Recombinant Antibody (clone Hu14G8v3); scfv Fragment | WB, FC, ELISA | Humanized scfv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0423CL | Human Anti-TTR Recombinant Antibody (TAB-0423CL) | ELISA, DB, WB, IF | Human IgG |
TAB-0423CL-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (TAB-0423CL-S(P)) | ELISA, DB, WB, IF | Human scFv |
TAB-0423CL-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (TAB-0423CL-F(E)) | ELISA, DB, WB, IF | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-166CQ | Mouse Anti-TTR Recombinant Antibody (TAB-166CQ) | ELISA, WB | Mouse IgG1, κ |
TAB-165CQ-S(P) | Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-165CQ-S(P)) | ELISA, WB | Mouse scFv |
TAB-166CQ-S(P) | Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-166CQ-S(P)) | ELISA, WB | Mouse scFv |
TAB-165CQ-F(E) | Mouse Anti-TTR Recombinant Antibody; Fab Fragment (TAB-165CQ-F(E)) | ELISA, WB | Mouse Fab |
TAB-166CQ-F(E) | Mouse Anti-TTR Recombinant Antibody; Fab Fragment (TAB-166CQ-F(E)) | ELISA, WB | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1684CT | Recombinant Mouse anti-Human TTR Monoclonal antibody (20F2) | IP, WB | |
VS3-QX1172 | Mouse Anti-TTR Recombinant Antibody (clone 10F7-2E8-5E8) | WB, IHC | Mouse IgG1 |
VS3-QX1173 | Mouse Anti-TTR Recombinant Antibody (clone 1F6-9A9-6A5) | WB, IHC | Mouse IgG1 |
VS3-QX1174 | Mouse Anti-TTR Recombinant Antibody (clone 1F7-4F7-2H10) | WB, IHC | Mouse IgG1 |
VS3-QX1175 | Mouse Anti-TTR Recombinant Antibody (clone 3B10-9F2-3H3) | WB, IHC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0600MZ | Chicken Anti-Transthyretin Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3717 | Rabbit Anti-TTR Recombinant Antibody (clone DS3717AB) | FC, ICC, IHC-P, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0108-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0108-YC-F(E)) | ELISA, FuncS | Human Fab |
HPAB-0109-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0109-YC-F(E)) | ELISA, WB, IP | Human Fab |
HPAB-0110-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0110-YC-F(E)) | ELISA, WB, IP | Human Fab |
HPAB-0111-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0111-YC-F(E)) | ELISA, WB, IP | Human Fab |
HPAB-0642LY-F(E) | Mouse Anti-TTR Recombinant Antibody (clone 14G8); Fab Fragment | WB, FC, ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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