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Mouse Anti-TTR Recombinant Antibody (clone AD7F6); scFv Fragment (CAT#: HPAB-0694-CN-S(P))

This is a monoclonal antibody which binds to human amyloidogenic transthyretin. The antibody AD7F6 can be used in screening for familial amyloidotic polyneuropathy (FAP) and pathologies presenting modified forms of TTR, and in research and treatment of associated diseases.


See more Engineered Antibody products for TTR
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  • Gene Expression
  • Datasheet
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line CACO-2
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
Figure 2 IHC staining of human hippocampus
Figure 2 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
Figure 3 IHC staining of human liver
Figure 3 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
Figure 4 IHC staining of human pancreas
Figure 4 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
Figure 5 IHC staining of human kidney
Figure 5 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
Normal Tissue
Figure 6 Liver
Figure 6 Liver
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
Figure 7 Pancreas
Figure 7 Pancreas
(Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
Figure 8 Kidney
Figure 8 Kidney
(Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR

Specifications

  • Immunogen
  • Recombinant mutant TTR Tyr78Phe
  • Host Species
  • Mouse
  • Type
  • Mouse scFv
  • Specificity
  • Human TTR
  • Species Reactivity
  • Human
  • Clone
  • AD7F6
  • Applications
  • WB, ELISA, IHC, IP
  • Related Disease
  • Alzheimer's disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • Transthyretin; Prealbumin, Amyloidosis Type I; PALB; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin;

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone AD7F6"

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Single-domain Antibody

CAT Product Name Application Type
NAB-2498-sdAb Recombinant Anti-human TTR VHH Single Domain Antibody ELISA, Neut, ICC, FC Llama VHH
HPAB-0483-YJ-VHH Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0483-YJ-VHH) ELISA Camel VHH
HPAB-0484-YJ-VHH Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0484-YJ-VHH) ELISA Camel VHH

Recombinant Antibody

CAT Product Name Application Type
MOB-2094z Mouse Anti-TTR Recombinant Antibody (clone 20F5) WB, ELISA, FC Mouse IgG1
PABZ-128 Mouse Anti-TTR Recombinant Antibody (clone 39-44) WB, Block Mouse IgG
MOB-1684CT Recombinant Mouse anti-Human TTR Monoclonal antibody (20F2) IP, WB
HPAB-0108-YC Human Anti-TTR Recombinant Antibody (HPAB-0108-YC) ELISA, FuncS Human IgG
MRO-2131-CN Rabbit Anti-TTR Polyclonal Antibody (MRO-2131-CN) WB, IF Rabbit IgG

Fab Fragment Antibody

CAT Product Name Application Type
PFBZ-128 Mouse Anti-TTR Recombinant Antibody (clone 39-44); Fab Fragment WB, Block Mouse Fab
HPAB-0642LY-F(E) Mouse Anti-TTR Recombinant Antibody (clone 14G8); Fab Fragment WB, FC, ELISA Mouse Fab
HPAB-0643LY-F(E) Human Anti-TTR Recombinant Antibody (clone Hu14G8v1); Fab Fragment WB, FC, ELISA Humanized Fab
HPAB-0644LY-F(E) Human Anti-TTR Recombinant Antibody (clone Hu14G8v2); Fab Fragment WB, FC, ELISA Humanized Fab
HPAB-0645LY-F(E) Human Anti-TTR Recombinant Antibody (clone Hu14G8v3); Fab Fragment WB, FC, ELISA Humanized Fab

scFv Fragment Antibody

CAT Product Name Application Type
PSBZ-128 Mouse Anti-TTR Recombinant Antibody (clone 39-44); scFv Fragment WB, Block Mouse scFv
HPAB-0108-YC-S(P) Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0108-YC-S(P)) ELISA, FuncS Human scFv
HPAB-0109-YC-S(P) Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0109-YC-S(P)) ELISA, WB, IP Human scFv
HPAB-0110-YC-S(P) Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0110-YC-S(P)) ELISA, WB, IP Human scFv
HPAB-0111-YC-S(P) Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0111-YC-S(P)) ELISA, WB, IP Human scFv

Human Antibody

CAT Product Name Application Type
TAB-0423CL Human Anti-TTR Recombinant Antibody (TAB-0423CL) ELISA, DB, WB, IF Human IgG
TAB-0423CL-S(P) Human Anti-TTR Recombinant Antibody; scFv Fragment (TAB-0423CL-S(P)) ELISA, DB, WB, IF Human scFv
TAB-0423CL-F(E) Human Anti-TTR Recombinant Antibody; Fab Fragment (TAB-0423CL-F(E)) ELISA, DB, WB, IF Human Fab

Mouse Antibody

CAT Product Name Application Type
TAB-165CQ Mouse Anti-TTR Recombinant Antibody (TAB-165CQ) ELISA, WB Mouse IgG1, κ
TAB-166CQ Mouse Anti-TTR Recombinant Antibody (TAB-166CQ) ELISA, WB Mouse IgG1, κ
TAB-165CQ-S(P) Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-165CQ-S(P)) ELISA, WB Mouse scFv
TAB-166CQ-S(P) Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-166CQ-S(P)) ELISA, WB Mouse scFv
TAB-165CQ-F(E) Mouse Anti-TTR Recombinant Antibody; Fab Fragment (TAB-165CQ-F(E)) ELISA, WB Mouse Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0600MZ Chicken Anti-Transthyretin Polyclonal IgY Indirect ELISA, WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3717 Rabbit Anti-TTR Recombinant Antibody (clone DS3717AB) FC, ICC, IHC-P, IP, WB Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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