Rabbit Anti-DDR1 Polyclonal Antibody (CAT#: VS3-WK1567)

• Immunogen
• Synthesized peptide derived from human DDR1

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human DDR1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB, ELISA

• Conjugate
• Unconjugated

• Clonality
• Polyclonal

• Purification
• Affinity purified

• Purity
• >95% as determined by SDS-PAGE

• Aggregation
• < 5%

• Format
• Liquid

• Concentration
• 1 mg/mL

• Buffer
• PBS, 0.5% BSA, 50% Glycerol

• Preservative
• 0.02% Sodium Azide

• Storage
• Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• This antibody has been tested for use in Western Blot (1:500) and ELISA (1:10000-1/20000).

• Alternative Names
• Discoidin Domain Receptor Tyrosine Kinase 1; CD167 Antigen-Like Family Member A; Protein-Tyrosine Kinase RTK-6; Mammary Carcinoma Kinase 10; Tyrosine-Protein Kinase CAK; Cell Adhesion Kinase; Tyrosine Kinase DDR; EC 2.7.10.1; EDDR1; NTRK4; PTK3A; HGK2; RTK6; TRKE; CAK; NEP; Epithelial Discoidin Domain-Containing Receptor 1

• Gene ID
• 780

• UniProt ID
• Q08345

• Long Name
• Discoidin Domain Receptor Tyrosine Kinase 1

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Autophosphorylated in response to fibrillar collagen binding.
  Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen.

• Protein Refseq
• NP_001189450.1

• Function
• Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity).

Secondary Antibody

• 2RD-A1460-YJ
• Goat Anti-Mouse IgG1 Secondary antibody

• 2RD-A1562-YJ
• Rabbit Anti-Mouse IgG1 Secondary antibody (Clone RM106)

• 2ND-047CQ
• Goat Anti-Mouse IgG1 Antibody, R-PE

• 2RD-A1517-YJ
• Sheep Anti-Rabbit IgG-heavy and light chain Secondary antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody