This product is a recombinant mouse antibody that recognizes VISTA. The antibody was purified by affinity chromatography. It can be used in Block, ELISA, FC.
Figure 1 VISTA-Ig–mediated suppression could overcome a moderate level of costimulation provided by CD28 but was completely reversed by a high level of costimulation, as well as partially rescued by exogenous IL-2.
(A and B) CFSE-labeled CD4+ T cells were activated by 2.5 µg/ml plate-bound ɑ-CD3 together with either VISTA-Ig or control-Ig at 1:1 and 1:2 ratios. (A) 40 ng/ml soluble mIL-2, mIL-7, mIL-15, or mIL-23 was also added as indicated to the cell culture. (B) 1 µg/ml ɑ-CD28 was immobilized together with 2.5 µg/ml ɑ-CD3 and Ig proteins at the indicated ratios. Cell proliferation was analyzed at 72 h by examining CFSE division profiles.
Wang, L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C., Guo, Y., ... & Noelle, R. J. (2011). VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. Journal of Experimental Medicine, 208(3), 577-592.
Figure 2 VISTA blockade using a specific mAb enhanced CD4+ T cell response in vitro and in vivo.
Wang, L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C., Guo, Y., ... & Noelle, R. J. (2011). VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. Journal of Experimental Medicine, 208(3), 577-592.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1126CL-S(P) | Mouse Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1126CL-S(P)) | FuncS | Mouse scFv |
TAB-1127CL-S(P) | Mouse Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1127CL-S(P)) | FC | Mouse scFv |
TAB-1128CL-S(P) | Mouse Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1128CL-S(P)) | ELISA, FC | Mouse scFv |
TAB-1132CL-S(P) | Hamster Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1132CL-S(P)) | ELISA, FC, Inhib | Hamster scFv |
TAB-1133CL-S(P) | Hamster Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1133CL-S(P)) | ELISA, FC | Hamster scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1129CL-S(P) | Human Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1129CL-S(P)) | ELISA | Humanized scFv |
TAB-1130CL-S(P) | Human Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1130CL-S(P)) | ELISA | Humanized scFv |
TAB-1131CL-S(P) | Human Anti-VISTA Recombinant Antibody; scFv Fragment (TAB-1131CL-S(P)) | ELISA | Humanized scFv |
TAB-1129CL-F(E) | Human Anti-VISTA Recombinant Antibody; Fab Fragment (TAB-1129CL-F(E)) | ELISA | Humanized Fab |
TAB-1130CL-F(E) | Human Anti-VISTA Recombinant Antibody; Fab Fragment (TAB-1130CL-F(E)) | ELISA | Humanized Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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