Rabbit Anti-YES1 Recombinant Antibody (clone R07-8B3) (CAT#: VS3-FY1940)

• Immunogen
• Synthetic peptide of human Yes1

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human YES1

• Species Reactivity
• Human

• Clone
• R07-8B3

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 61 kDa, while the observed molecular weight stands at 61 kDa.

• Related Disease
• Sarcoma and Colorectal Cancer

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• YES Proto-Oncogene 1, Src Family Tyrosine Kinase; V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1; Proto-Oncogene C-Yes; EC 2.7.10.2; P61-YES; Yes; YES1 Proto-Oncogene, Src Family Tyrosine Kinase; Proto-Oncogene Tyrosine-Protein Kinase YES

• Gene ID
• 7525

• UniProt ID
• P07947

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Cytoskeleton, Membrane

• Post Translation Modifications
• Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state.
  Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
  (P07947-YES_HUMAN)
  Palmitoylation at Cys-3 promotes membrane localization. (P07947-YES_HUMAN)
  Ubiquitination at Lys235 (NX_P07947 [NX_P07947-1])
  Modification sites at PhosphoSitePlus (P07947)
  Glycosylation from GlyGen (P07947) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005258196.1; XP_016881449.1; XP_024307011.1; XP_024307012.1; XP_024307013.1

• Function
• Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody