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Recombinant Human Anti-MDM2 Soluble TCR (1bd2) (KIH) (CAT#: VS-0622-YF5621)

Human TCR (1bd2) recognizes MDM2 peptide (aa 81-88) in the context of HLA-A2.1. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.


See more Soluble T Cell Receptor products for MDM2
Specific Inquiry
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  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16303/if_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79977/1999_F7_3_selected.jpg
Figure 3 IHC staining of human cerebellum
Figure 3 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong nuclear positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/ihc_selected.jpg
Figure 4 IHC staining of human ovary
Figure 4 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16303/37938_A_6_7_selected.jpg
Figure 5 IHC staining of human placenta
Figure 5 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong nuclear and cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79977/170698_A_2_7_selected.jpg
Normal Tissue
Figure 6 Cerebral cortex
Figure 6 Cerebral cortex
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Glial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_B_8_5.jpg
Figure 7 Colon
Figure 7 Colon
(Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Glandular cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Peripheral nerve/ganglion
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_9_3.jpg
Figure 8 Liver
Figure 8 Liver
(Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Hepatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_8_4.jpg
Figure 9 Pancreas
Figure 9 Pancreas
(Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Pancreatic endocrine cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_2_3.jpg
Figure 10 Kidney
Figure 10 Kidney
(Cells in glomeruli
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_8_5.jpg
Figure 11 Testis
Figure 11 Testis
(Pachytene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Peritubular cells
Staining: High
Intensity: Strong
Quantity:>75%
Preleptotene spermatocytes
Staining: High
Intensity: Strong
Quantity:>75%
Round or early spermatids
Staining: High
Intensity: Strong
Quantity:>75%
Spermatogonia cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_5_6.jpg
Figure 12 Lymph node
Figure 12 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/86/33293_A_9_8.jpg
RNA Expression
Figure 13 RNA cell line category: Cell line enhanced (HBEC3-KT, U-698)
Figure 13 RNA cell line category: Cell line enhanced (HBEC3-KT, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135679-MDM2

Specifications

  • Host Species
  • Human
  • Target
  • MDM2
  • Species Reactivity
  • Human
  • Epitope
  • aa 81-88
  • MHC
  • HLA-A2.1
  • Clone
  • 1bd2
  • Type
  • Soluble TCR (KIH)
  • Related Disease
  • Cancer
  • TCR Expression Strategy
  • KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).

Target

  • Alternative Names
  • HDMX; hdm2; ACTFS

Related Resources

  • Related Diseases
  • Related Signaling Pathways

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-648 Recombinant Anti-human MDM2 Antibody ELISA, WB, IF, FuncS IgG
MHH-648 Recombinant Human Anti-human MDM2 Antibody IP, RIA, FuncS IgG
MOB-1012CT Recombinant Mouse anti-Human MDM2 Monoclonal antibody (3H3) WB
VS3-XY1056 Mouse Anti-MDM2 Recombinant Antibody (clone 3G2) WB, IP, IF, IHC Mouse IgG1
VS3-WK838 Mouse Anti-MDM2 Recombinant Antibody (VS3-WK838) WB Mouse IgG

Fab Fragment Antibody

CAT Product Name Application Type
MOB-648-F(E) Recombinant Anti-human MDM2 Antibody Fab Fragment WB, FACS, FuncS Fab
MHH-648-F(E) Recombinant Human Anti-human MDM2 Antibody Fab Fragment ELISA, WB, FC, FuncS Fab

scFv Fragment Antibody

CAT Product Name Application Type
MOB-648-S(P) Recombinant Anti-human MDM2 Antibody scFv Fragment ELISA, WB, FuncS scFv
MHH-648-S(P) Recombinant Human Anti-human MDM2 Antibody scFv Fragment ELISA, WB, FC, FuncS scFv

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0353MZ Chicken Anti-MDM2 Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4642 Hi-Affi™ Recombinant Rabbit Anti-MDM2 Monoclonal Antibody (TH155DS) WB, IF, ICC IgG

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-CN1420 PE-A*02:01/Human MDM2 (LLGDLFGV) MHC Tetramer FCM
MHC-YF287 A*02:01/Human MDM2 (LLGDLFGV) MHC Monomer MHC Multimer

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