A431, OVCAR3, BxPC3 and HT-29 (clone mAb2)-AcLys-Putrescinyl-Geldanamycin ADC (CAT#: ADC-277CL)
This ADC product is composed of an anti-A431, OVCAR3, BxPC3 and HT-29 antibody (clone mAb2) conjugated via AcLys-Putrescinyl linker to Geldanamycin(mAb2-HCQ01-AcLys-Putrescinyl-
Geldanamycin).
Specific Inquiry
Specifications
- Antibody Overview
- mAb2 (a Chimeric IgG1 Antibody) HCQ01
- Clone
- mAb2
- Antibody Isotype
- IgG1
- Linker
- AcLys-Putrescinyl
- Drug
- Geldanamycin
- Drug Class/Description
- Geldanamycin is a 1,4-benzoquinone ansamycin antitumor antibiotic that inhibits the function of Hsp90 (Heat Shock Protein 90) by binding to the unusual ADP/ATP-binding pocket of the protein. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.
Hsp90-geldanamycin complex. PDB 1yet
Geldanamycin induces the degradation of proteins that are mutated in tumor cells such as v-Src, Bcr-Abl and p53 preferentially over their normal cellular counterparts. This effect is mediated via HSP90. Despite its potent antitumor potential, geldanamycin presents several major drawbacks as a drug candidate such as hepatotoxicity, further, Jilani et al. reported that geldanamycin induces the apoptosis of erythrocytes under physiological concentrations.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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