A431, OVCAR3, BxPC3 and HT-29 (clone mAb2)-Aminocaproyl-MMAE ADC (CAT#: ADC-282CL)
This ADC product is composed of an anti-A431, OVCAR3, BxPC3 and HT-29 antibody (clone mAb2) conjugated via Aminocaproyl linker to MMAE(mAb2-HCQ01-Aminocaproyl-MMAE). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Specifications
- Antibody Overview
- mAb2 (a Chimeric IgG1 Antibody) HCQ01
- Clone
- mAb2
- Antibody Isotype
- IgG1
- Linker
- Aminocaproyl
- Drug
- MMAE (Monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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