Recombinant Mouse Anti-KRT10 Antibody (clone 4E5-10C9-7B1) (CAT#: VS3-FY805)
This product is a recombinant mouse antibody that recognizes KRT10. This antibody has been reported for use in Immunohistochemistry-Paraffin. The clone 4E5-10C9-7B1 is specific for human KRT10. The antigen is synthetic peptide derived from human cytokeratin 10.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in skin 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12014/ihc_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12014/ihc_selected.jpg
Figure 2 Low expression in colon
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12014/143516_A_8_3_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12014/143516_A_8_3_val_selected.jpg
Figure 3 Skin
(Cells in corneal layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in granular layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity:>75% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/132/2531_B_8_1.jpg
(Cells in corneal layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in granular layer Staining: Medium Intensity: Moderate Quantity:>75% Cells in spinous layer Staining: Medium Intensity: Moderate Quantity:>75% Eccrine glands Staining: Medium Intensity: Moderate Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/132/2531_B_8_1.jpg
Figure 4 RNA cell line category: Cell line enriched (hTCEpi)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186395-KRT10
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000186395-KRT10
Specifications
- Immunogen
- Synthetic peptide derived from human cytokeratin 10.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human KRT10
- Species Reactivity
- Human
- Clone
- 4E5-10C9-7B1
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity Chromatography
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS, pH 7.3, 50% glycerol, 0.5% BSA
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry-Paraffin: 1/100-1/500
Target
- Alternative Names
- Keratin 10; Keratin 10, Type I; Cytokeratin 10; CK-10; KPP; K10; Keratosis Palmaris Et Plantaris; Keratin, Type I Cytoskeletal 10
- Gene ID
- 3858
- UniProt ID
- P13645
- Sequence Similarities
- Belongs to the intermediate filament family.
- Cellular Localization
- Intermediate filament, Keratin, Secreted
- Protein Refseq
- NP_000412.3
- Function
- Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity).
Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity).
(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.
(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
Recommended Products
Secondary Antibody
Isotype Control
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KRT10"
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1975 | Hi-Affi™ Recombinant Rabbit Anti-KRT10 Monoclonal Antibody (DS1975AB) | ICC, IHC-P, IP, WB | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0230J | Mouse Anti-KRT10 Recombinant Antibody (ZG-0230J) | IHC-P, IF | Mouse IgG |
| ZG-0231J | Mouse Anti-KRT10 Recombinant Antibody (ZG-0231J) | IHC-P, IF | Mouse IgG |
| ZG-0582F | Mouse Anti-KRT10 Recombinant Antibody (clone DE-K10) | IHC-Fr, IHC-P | Mouse IgG1 |
| ZG-1087F | Mouse Anti-KRT10 Recombinant Antibody (clone RKSE60) | FC, ICC, IHC-Fr, WB | Mouse IgG1 |
| VS1-YJ41 | Mouse Anti-KRT10 Recombinant Antibody (clone AE20) | IHC-P, IHC-Fr, WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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