Recombinant Mouse Anti-PEG10 Antibody (VS4-CJ71) (CAT#: VS4-CJ71)
This mouse anti-PEG10 antibody is a product that recognizes human, mouse, rabbit, porcine PEG10. The immunogen of this antibody is a purified recombinant human PEG10 protein fragment expressed in E. coli. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/762_H11_1_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/762_H11_1_selected.jpg
Figure 2 High expression in placenta
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_2_7_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_2_7_selected.jpg
Figure 3 Low expression in prostate
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_3_5_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21324/47975_A_3_5_val_selected.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_5_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_5_6.jpg
Figure 5 Placenta
(Cytotrophoblasts Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_1_7.jpg
(Cytotrophoblasts Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51038/137897_A_1_7.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, Hep G2, SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000242265-PEG10
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000242265-PEG10
Specifications
- Immunogen
- Purified recombinant human PEG10 protein fragments expressed in E. coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human, Mouse, Rabbit, Porcine PEG10
- Species Reactivity
- Human, Mouse, Rabbit, Porcine
- Applications
- ELISA, WB, IP
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
- Preservative
- 0.2% Sodium Azide
- Storage
- Store at -20°C or -80°C upon receipt. Avoid repeated freeze.
Applications
- Application Notes
- This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000), Immunoprecipitation (1:200-1:2000).
Target
- Alternative Names
- EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1
- Gene ID
- 23089
- UniProt ID
- Q86TG7
- Long Name
- Paternally expressed 10
- Cellular Localization
- Cytoplasm, Membrane, Nucleus
- Post Translation Modifications
- Isoform 1: Undergoes proteolytic cleavage.
- Protein Refseq
- NP_001035242.1; NP_001165908.1; NP_001165909.1
- Function
- Retrotransposon-derived protein that binds its own mRNA and self-assembles into virion-like capsids (PubMed:34413232).
Forms virion-like extracellular vesicles that encapsulate their own mRNA and are released from cells, enabling intercellular transfer of PEG10 mRNA (PubMed:34413232).
Binds its own mRNA in the 5'-UTR region, in the region near the boundary between the nucleocapsid (NC) and protease (PRO) coding sequences and in the beginning of the 3'-UTR region (PubMed:34413232).
Involved in placenta formation: required for trophoblast stem cells differentiation (By similarity).
Involved at the immediate early stage of adipocyte differentiation (By similarity).
Overexpressed in many cancers and enhances tumor progression: promotes cell proliferation by driving cell cycle progression from G0/G1 (PubMed:12810624, PubMed:16423995, PubMed:26235627, PubMed:28193232).
Enhances cancer progression by inhibiting the TGF-beta signaling, possibly via interaction with the TGF-beta receptor ACVRL1 (PubMed:15611116, PubMed:26235627, PubMed:30094509).
May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter; additional evidences are however required to confirm this result (By similarity).
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "PEG10"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0970MZ | Recombinant Mouse Anti-Human PEG10 Antibody (clone 2C2D5) | ELISA, WB | Mouse antibody |
| ZG-0366C | Mouse Anti-PEG10 Recombinant Antibody (ZG-0366C) | WB | Mouse IgG |
| ZG-0367C | Mouse Anti-PEG10 Recombinant Antibody (ZG-0367C) | WB, IHC, ELISA | Mouse IgG |
| VS3-QX867 | Mouse Anti-PEG10 Recombinant Antibody (clone 1B1C4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-XY1244 | Mouse Anti-PEG10 Recombinant Antibody (clone 4C10A7) | ELISA, WB, IHC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2660 | Hi-Affi™ Recombinant Rabbit Anti-PEG10 Monoclonal Antibody (DS2660AB) | WB, ICC/IF | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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