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Recombinant Mouse Anti-SDCBP Antibody (VS4-CJ109) (CAT#: VS4-CJ109)

This mouse anti-SDCBP antibody is a product that recognizes human, dog, rat, porcine SDCBP. The immunogen of this antibody is a purified recombinant human SDCBP protein fragment expressed in E. coli. The mAb has been tested for use in ELISA, Western Blot (1:500-1:5000).


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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/if_selected.jpg
Figure 2 IHC staining of human prostate
Figure 2 IHC staining of human prostate
(Immunohistochemical staining of human prostate shows strong positivity in peripheral nerves.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/ihc_selected.jpg
Figure 3 IHC staining of human vulva/anal skin
Figure 3 IHC staining of human vulva/anal skin
(Immunohistochemical staining of human vulva/anal skin shows distinct cytoplasmic positivity in melanocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/ihc_selected.jpg
Figure 4 IF staining of human cell line U-2 OS
Figure 4 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/241_E2_1_red_green.jpg
Figure 5 IF staining of human cell line U-251 MG
Figure 5 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23840/239_E2_1_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Figure 6 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_8_5.jpg
Figure 7 Colon
Figure 7 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_7_3.jpg
Figure 8 Skin
Figure 8 Skin
(Epidermal cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_B_5_8.jpg
Figure 9 Lymph node
Figure 9 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12245/31141_A_9_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (HHSteC)
Figure 10 RNA cell line category: Cell line enhanced (HHSteC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000137575-SDCBP

Specifications

  • Immunogen
  • Purified recombinant human SDCBP protein fragments expressed in E. coli.
  • Host Species
  • Mouse
  • Type
  • Mouse IgG2b
  • Specificity
  • Human, Dog, Rat, Porcine SDCBP
  • Species Reactivity
  • Human, Dog, Rat, Porcine
  • Applications
  • ELISA, WB
  • Conjugate
  • Unconjugated

Product Property

  • Purification
  • Affinity purified
  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Buffer
  • 50% Glycerol, 0.1M Tris-Glycine (150 mM NaCl), pH 7.4.
  • Preservative
  • 0.2% Sodium Azide
  • Storage
  • Store at -20°C or -80°C upon receipt. Avoid repeated freeze.

Applications

  • Application Notes
  • This antibody has been tested for use in ELISA, Western Blot (1:500-1:5000).

Target

  • Alternative Names
  • ST1; MDA9; SYCL; MDA-9; TACIP18
  • Long Name
  • Syndecan binding protein
  • Cellular Localization
  • Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted
  • Post Translation Modifications
  • Phosphorylated on tyrosine residues.
  • Function
  • Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527).
    Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292).
    In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).
    Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120).
    In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591).
    May also play a role in vesicular trafficking (PubMed:11179419).
    Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "SDCBP"

Single-domain Antibody

CAT Product Name Application Type
NAB-1089-VHH Recombinant Anti-human SDCBP VHH Single Domain Antibody WB, IP, ICC, FC, FA Llama VHH

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3191 Hi-Affi™ Recombinant Rabbit Anti-SDCBP Monoclonal Antibody (DS3191AB) WB, IHC, ICC, IP, FC IgG

Recombinant Antibody

CAT Product Name Application Type
MRO-1465-CN Recombinant Rabbit Anti-SDCBP Monoclonal Antibody (JE40-72) WB, IF, IHC, FC, IP Rabbit IgG
VS3-WK345 Rabbit Anti-SDCBP Recombinant Antibody (clone JE40-72) WB, ELISA Rabbit IgG
VS4-CJ108 Recombinant Mouse Anti-SDCBP Antibody (clone 2A3E2) ELISA, WB Mouse IgG2b

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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