Recombinant Rabbit Anti-THBD Detection Antibody (clone R08-5H0) (CAT#: VS3-WK1699)
This antibody is a rabbit recombinant antibody against human THBD. It was developed by immunization of rabbit with recombinant human THBD protein and then was produced as a recombinant antibody. The isotype of this product is rabbit IgG. R01-4F4 and R08-5H0 were identified as antibody pair for sandwich ELISA. As a detection antibody, the clone R08-5H0 can be used in ELISA analysis to identify human THBD.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/29_E4_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/29_E4_2_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/ihc_selected.jpg
Figure 3 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows luminal positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows luminal positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/ihc_selected.jpg
Figure 4 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/30_E4_1_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2982/30_E4_1_red_green.jpg
Figure 5 Colon
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_7_3.jpg
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_7_3.jpg
Figure 6 Placenta
(Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_3_7.jpg
(Trophoblastic cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2425/6389_A_3_7.jpg
Figure 7 RNA cell line category: Cell line enhanced (ASC diff, CAPAN-2, EFO-21, HaCaT, hTCEpi, OE19, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178726-THBD
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178726-THBD
Specifications
- Immunogen
- Recombinant human THBD protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human THBD
- Species Reactivity
- Human
- Clone
- R08-5H0
- Applications
- ELISA
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Aggregation
- < 5%
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 0.01M PBS, pH 7.2
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Thrombomodulin; CD141 Antigen; Fetomodulin; THRM; TM; THPH12; AHUS6; BDCA3; CD141
- Gene ID
- 7056
- UniProt ID
- P07204
- Long Name
- Thrombomodulin
- Cellular Localization
- Membrane
- Post Translation Modifications
- N-glycosylated.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
- Protein Refseq
- NP_000352.1
- Function
- Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
Recommended Products
Capture antibody
Isotype Control
Secondary Antibody
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1329-VHH | Recombinant Anti-Mouse Thbd VHH Single Domain Antibody | IHC, ICC, FC, FA, FUNC | Llama VHH |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1171z | Mouse Anti-THBD Recombinant Antibody (clone 36C5) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MRO-1490-CN | Rabbit Anti-THBD Recombinant Antibody (clone JB48-23) | WB, IHC, IP | Rabbit IgG |
| VS4-CJ135 | Recombinant Rabbit Anti-THBD Antibody (clone 15C7) | ELISA, IHC | Rabbit IgG |
| VS3-FY1449 | Recombinant Rabbit Anti-Thbd Antibody (clone R02-1G1) | WB | Rabbit IgG |
| VS3-WK1698 | Recombinant Rabbit Anti-THBD Capture Antibody (clone R01-4F4) | ELISA | Rabbit IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3559 | Rabbit Anti-THBD Recombinant Antibody (clone DS3559AB) | WB | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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