Disease related genes, Human disease related genes, Transcription factors
Intracellular
Cell type enriched (Melanocytes)
Not detected in immune cells
Cell line enhanced (HAP1, HEK93, HUVEC TERT2, SK-MEL-30, THP-1, WM-115)
Binds DNA as a homodimer; required for transcriptional activation (PubMed:9753625). Interacts (via homeobox domain) with EP300; acetylates ALX1 and stimulates its transcriptional activity.
Activator, Developmental protein, DNA-binding, Repressor
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For Research Use Only. Not For Clinical Use.