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CACNA1D
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Transporters, Voltage-gated ion channels
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Microglial cells)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (HMC-1, RPMI-8226, SK-BR-3)
Interaction
Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Channel activity is further modulated, depending on the presence of specific delta subunit isoforms. Interacts (via IQ domain) with CABP1 and CABP4 in a calcium independent manner (By similarity). Interacts with RIMBP2 (By similarity).
Molecular function
Calcium channel, Ion channel, Voltage-gated channel
More Types Infomation
- PE-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (MHC-LC1589)
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- Class: Class I
- Antigen: CACNA1D
- Antigen Species: Human
- Peptide: SRRWRRWNR
- Conjugate: PE
- BV421-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (MHC-LC1591)
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- Class: Class I
- Antigen: CACNA1D
- Antigen Species: Human
- Peptide: SRRWRRWNR
- Conjugate: BV421
- APC-B*27:05/Human CACNA1D (SRRWRRWNR) MHC Tetramer (MHC-LC1590)
-
- Class: Class I
- Antigen: CACNA1D
- Antigen Species: Human
- Peptide: SRRWRRWNR
- Conjugate: APC
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For Research Use Only. Not For Clinical Use.