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CD79b & CD3
CD79B (CD79b Molecule) is a Protein Coding gene. Diseases associated with CD79B include Agammaglobulinemia 6, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity.
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
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- Targets: CD79b & CD3
- Type: Fab2
- Application: FuncS, Promising therapeutic agent
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, FuncS
- Rat Anti-CD3 Recombinant Antibody (clone 17A2) (MOB-0202MC)
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- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: FC, IHC, IP, Activ, CMCD, Depletion
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Fab fragment
- Application: ELISA
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG1, κ
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
- Anti-CD79b (clone SN8)-SPP-DM1 ADC (ADC-201LZY)
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- Target: CD79b
- Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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- Target: CD79b
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
- Anti-CD79b (clone hu2F2.D7)-MCvcPAB-MMAE ADC (ADC-206CL)
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- Target: CD79b
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
- Anti-CD79b-MCC-DM1 ADC (ADC-084LZY)
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- Target: CD79b
- Linker: MCC (4-(Nmaleimidomethyl)cyclohexane-1 carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Anti-CD79 (bSN8)-mcc-DM1 ADC (ADC-089LCT)
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- Target: CD79b
- Linker: mcc (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Anti-CD79b (clone huMA79b.v28)-BMPEO-DM1 ADC (ADC-052CL)
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- Target: CD79b
- Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Anti-CD79b (clone hu2F2.D7)-MC-MMAF ADC (ADC-205CL)
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- Target: CD79b
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
- Anti-CD79b-vc-MMAE ADC (ADC-034LZY)
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- Target: CD79b
- Linker: VC(Valine-citrulline)
- Drug: MMAE (monomethyl auristatin E)
- THIO-Anti-CD79b (Polatuzumab)-MC-VC-PABC-MMAE ADC (ADC-088LCT)
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- Target: CD79b
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
- Anti-CD79b (clone huMA79b.v28)-MC-MMAF ADC (ADC-051CL)
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- Target: CD79b
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
- Anti-CD79b (clone hu2F2.D7)-BMPEO-DMl ADC (ADC-204CL)
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- Target: CD79b
- Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Anti-CD79b (Polatuzumab)-vc-MMAE ADC (ADC-087LCT)
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- Target: CD79b
- Linker: VC (valine-citrulline)
- Drug: MMAE (Monomethyl auristatin E)
- Anti-CD79b (clone hu2F2.D7)-SMCC-DM1 ADC (ADC-203CL)
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- Target: CD79b
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Anti-CD79b (clone huMA79b.v18)-MCvcPAB-MMAE ADC (ADC-050CL)
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- Target: CD79b
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
- Anti-CD79b (clone ch2F2)-SMCC-DM1 ADC (ADC-202CL)
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- Target: CD79b
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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For Research Use Only. Not For Clinical Use.