Intracellular, Membrane (different isoforms)
Group enriched (Langerhans cells, Macrophages, Hofbauer cells)
Immune cell enriched (classical monocyte)
Group enriched (HL-60, U-937)
Monomer (PubMed:21566123). Homodimer (PubMed:21566123). The majority of CLEC5A is expressed as a monomeric form on macrophages (PubMed:21566123). Interacts with TYROBP/DAP12 (PubMed:10449773). The interaction with TYROBP is required for CLEC5A cell surface expression (PubMed:10449773). Interacts with HCST/DAP10 (By similarity). Forms a CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). (Microbial infection) Interacts with dengue virus envelope protein E (PubMed:18496526, PubMed:21566123).
Host cell receptor for virus entry, Receptor
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For Research Use Only. Not For Clinical Use.