Disease related genes, Human disease related genes, Potential drug targets, Transporters
Intracellular, Membrane (different isoforms)
Cell type enhanced (Hofbauer cells, Plasma cells, NK-cells, Kupffer cells, monocytes, Macrophages, dendritic cells)
Immune cell enhanced (eosinophil)
Cell line enhanced (MCF7, RPMI-8226, THP-1)
Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9) (PubMed:22808130). Interacts with GBP7 (By similarity).
Oxidoreductase
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For Research Use Only. Not For Clinical Use.