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DHCR7
The DHCR7 gene encodes delta-7-sterol reductase (EC 1.3.1.21), the ultimate enzyme of mammalian sterol biosynthesis that converts 7-dehydrocholesterol (7-DHC) to cholesterol. This enzyme removes the C(7-8) double bond introduced by the sterol delta8-delta7 isomerases. In addition, its role in drug-induced malformations is known: inhibitors of the last step of cholesterol biosynthesis such as AY9944 and BM15766 severely impair brain development.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Hepatocytes, Theca cells, Granulosa cells, Basal respiratory cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with DHCR24; this interaction regulates DHCR7 activity.
Molecular function
Oxidoreductase
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ICC, IP
- Recombinant Anti-Human DHCR7 Antibody scFv Fragment (MOB-3962z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
- Recombinant Anti-Human DHCR7 Antibody Fab Fragment (MOB-3962z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, FacS, FuncS
- Mouse Anti-DHCR7 Recombinant Antibody (VS-0224-XY34) (VS-0224-XY34)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IP, IHC, ICC
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For Research Use Only. Not For Clinical Use.