Enzymes
Intracellular
Low cell type specificity
Low immune cell specificity
Cell line enhanced (HBEC3-KT)
Homodimer (PubMed:16475979, PubMed:29382749). Forms a ternary complex with NLRP1, composed of a DPP9 homodimer, one full-length NLRP1 protein, and one cleaved C-terminus of NLRP1 (NACHT, LRR and PYD domains-containing protein 1, C-terminus) (PubMed:33731929, PubMed:33731932). Forms a ternary complex with CARD8, composed of a DPP9 homodimer, one full-length NLRP1 protein, and one cleaved C-terminus of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) (PubMed:33731929, PubMed:34019797). In the ternary complex, only one subunit of the DPP9 homodimer is bound to NLRP1 or CARD8 (PubMed:34019797, PubMed:33731932).
Aminopeptidase, Hydrolase, Protease, Serine protease
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For Research Use Only. Not For Clinical Use.