Intracellular
Cell type enhanced (Spermatocytes, Erythroid cells, Early spermatids, Spermatogonia, Extravillous trophoblasts)
Immune cell enhanced (T-reg)
Low cell line specificity
Component of the DCX(DTL) E3 ubiquitin ligase complex (also called CRL4(CDT2)), at least composed of CUL4 (CUL4A or CUL4B), DDB1, DTL/CDT2 and RBX1 (PubMed:16861906, PubMed:17085480, PubMed:16949367, PubMed:17041588, PubMed:18794347, PubMed:18794348, PubMed:23478441). Interacts with CDKN1A (PubMed:23213251). Interacts with DDB1 (PubMed:16949367, PubMed:23478445). Interacts with FBXO11; SCF(FBXWO11) controls DTL stability but DCX(DTL) does not control FBXO11 stability (PubMed:23478445, PubMed:23478441). Interacts with CRY1 (PubMed:26431207).
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For Research Use Only. Not For Clinical Use.