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EDNRB
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
Protein class
Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Sertoli cells, Astrocytes, Adipocytes, Muller glia cells, Hepatic stellate cells, Melanocytes, Smooth muscle cells, Skeletal myocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, ASC diff, SK-MEL-30, U-266/70, WM-115)
Molecular function
G-protein coupled receptor, Receptor, Transducer
More Types Infomation
- Recombinant Human Anti-human EDNRB Antibody Fab Fragment (MHH-302-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: RIA, IP, FuncS
- Recombinant Human Anti-human EDNRB Antibody scFv Fragment (MHH-302-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, IHC, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IP, FuncS
- Recombinant Anti-human EDNRB Antibody Fab Fragment (MOB-302-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, FuncS
- Recombinant Anti-human EDNRB Antibody scFv Fragment (MOB-302-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IP, FuncS
- Rabbit Anti-EDNRB Recombinant Antibody (clone JM74-10) (MRO-0534-CN)
-
- Species Reactivity: Human, Zebrafish
- Type: Rabbit IgG
- Application: WB, IP
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IP, FC
- Recombinant Anti-human EDNRB Antibody (MOB-302)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FuncS
- Anti-Human EDNRB Recombinant Antibody scFv Fragment (Rendomab-BI) (TAB-013WM-S(P))
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- Species Reactivity: Human
- Application: ELISA, FC
- Anti-ETBR-vc-MMAE ADC (ADC-124LZY)
-
- Target: ETBR
- Linker: VC (valine-citrulline)
- Drug: MMAE (monomethyl auristatin E)
- Anti-EDNBR (clone 5E9)-vc-MMAE ADC (ADC-169LZY)
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- Target: EDNBR
- Linker: VC (valine-citrulline)
- Drug: MMAE (monomethyl auristatin E)
-
- Species Reactivity: Human
- Application: ELISA, FC
- Anti-ET8R (endothelin B)-vc-MMAE ADC (ADC-093LZY)
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- Target: ET8R (endothelin B)
- Linker: VC (valine-citrulline)
- Drug: MMAE(monomethyl auristatin E)
- Anti-Human EDNRB Recombinant Antibody Fab Fragment (Rendomab-BI) (TAB-013WM-F(E))
-
- Species Reactivity: Human
- Application: ELISA, FC
- Mouse Anti-EDNRB Recombinant Antibody; scFv Fragment (HPAB-N0078-YC-S(P)) (HPAB-N0078-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-EDNRB Recombinant Antibody; Fab Fragment (HPAB-N0078-YC-F(E)) (HPAB-N0078-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-EDNRB Recombinant Antibody (HPAB-N0078-YC) (HPAB-N0078-YC)
-
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, FC
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For Research Use Only. Not For Clinical Use.